雷贝拉唑、阿莫西林克拉维酸、替硝唑三联对幽门螺杆菌的疗效观察  

Effect of trilogy treatment of rabeprazole,amoxicillin and clavulanate potassium and tinidazole on eradication Helicobacter pylori infection

作　　者：张传军[1] 鲁惠敏[1] 

机构地区：[1]河南省人民医院,郑州450003

出　　处：《临床医学》2008年第5期17-18,共2页Clinical Medicine

摘　　要：目的观察雷贝拉唑、阿莫西林克拉维酸、替硝唑三联疗法对幽门螺杆菌的根除和消化性溃疡的治疗作用。方法82例Hp阳性的消化性溃疡患者给予雷贝拉唑10 mg、替硝唑500 mg,2次/天,阿莫西林克拉维酸312.5 mg,3次/d,连服7 d,观察腹痛缓解率、溃疡愈合率、Hp根除率和不良反应的发生率。结果临床腹痛缓解率为97.6%,治疗结束后Hp根除率为92.6%,溃疡愈合率为93.9%,不良反应的发生率为6.1%。结论雷贝拉唑、阿莫西林克拉维酸、替硝唑三联疗法是一种治疗幽门螺杆菌感染和消化性溃疡的安全、有效、快速的方法。Objective To evaluate the efficacy of the triple therapies of rabeprazole, amoxicillin and clavulanate potassium and tinidazole on the eradication of Helicobacter pylori （Hp） and peptic ulcer. Methods Eighty - two cases of Hp - positive patients with peptic ulcer were accepted one -week triple therapy with amoxicillin clavulanic acid 312.5 mg, 3 times/day, tinidazole 500 mg and rabeprazole 10 mg, 2 times/day. Abdominal pain remission rate, Hp eradication rate, ulcer healing rate and adverse reactions rate were observed. Results Abdominal pain remission rate was 100%. Hp eradication rate was 92.6%, ulcer healing rate was 93.9% and adverse reactions rate was 6. 1% after treatment was finished. Conclusion The triple therapy composed of rabeprazole ,amoxicillin and clavulanate potassium and tinidazole is safe and effective in treatment of Hp infection and peptic ulcer.

关 键 词：幽门螺杆菌 三联疗法 雷贝拉唑 阿莫西林克拉维酸 替硝唑 

分 类 号：R573.1[医药卫生—消化系统]