脑血流动力学与缺血性卒中发病风险的关系  

The Relationship between Cerebrovascular Hemodynamics and Risk of Ischemic Stroke

作　　者：郭吉平[1] 黄久仪[1] 张凤英 杨永举[1] 曹奕丰[1] 王桂清[1] 

机构地区：[1]上海市脑血管病防治研究所,上海201318 [2]通钢集团吉林钢铁有限公司职工医院,吉林磐石132301

出　　处：《中国慢性病预防与控制》2008年第3期225-227,共3页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家自然科学基金资助项目(39370612);上海市科技发展基金资助项目(934113060,944912014)

摘　　要：目的探讨脑血管血流动力学指标(CVHI)积分与缺血性脑卒中发病风险的关系。方法以巢式病例-对照研究设计,选择东北地区队列人群中新发生的151例缺血性卒中病例为研究对象,并将年龄、性别作为匹配条件,在同一人群中随机选取同等数量的非卒中个体为对照,分析和比较CVHI积分值降低及卒中常见危险因素暴露与缺血性卒中发病的风险。结果单因素分析显示,CVHI积分、高血压病史、心脏病史、卒中家族史与缺血性卒中发病风险具有显著的病因学联系(P<0.05),其OR(95%CI)分别为6.75(3.93～11.62)、3.44(2.01～5.90)、1.77(1.01～3.10)、2.04(1.12～3.72)。CVHI积分值与缺血性卒中发病风险具有显著的剂量反应关系,随积分值降低,发病风险上升(趋势χ2=48.48,P=0.001)。多因素Logistic回归分析显示,被筛选进入方程的因素分别为CVHI积分、高血压病史、卒中家族史,其中CVHI作用最强,OR(95%CI)为6.122(3.474～10.789)。结论CVHI积分值降低与缺血性卒中发病风险增加密切相关,可能是其独立的预测因子。Objective To probe into the relations between cerebrovascular hemodynamics indexes（CVHI）,risk factors of stroke and risk of ischemic stroke.Methods A nested case-control design was used in the study.Participants were selected from a cohort in the northeast of China.151 ischemic stroke patients occurred during the follow-up term were defined as case group,and the same numbers of individuals,free of stroke,were selected randomly in the cohort and defined as control group.Odds ratio（OR） of CVHI score as well as other risk factors of stroke were estimated.Results Univariate analysis indicated that there were significant etiological relations between stroke and CVHI score,hypertension,heart disease and family history of stroke（P〈0.05）,and the OR of these factors were 6.75,3.44,1.77 and 2.04,respectively.Dosage response between stroke risk and CVHI score was significant.Multiple Logistic regression showed that the factors being selected into question were CVHI score,history of hypertension and family history of stroke.Conclusions There is a significant correlation between decreasing of CVHI score and risk of ischemic stroke.It may be an independent predictor of ischemic stroke.

关 键 词：脑血管意外 血流动力学 危险因素 巢式病例对照研究 

分 类 号：R743.3[医药卫生—神经病学与精神病学]