Skp2和p27^(kip1)蛋白在前列腺癌组织中的表达及临床意义  

Correlations between Skp2 and p27^(kip1) protein expressions and clinicopathological features of prostate cancer

作　　者：周晓峰[1] 郑祥毅[2] 

机构地区：[1]中日友好医院泌尿外科,北京100029 [2]浙江大学第一附属医院泌尿外科,杭州310003

出　　处：《中日友好医院学报》2008年第3期160-161,164,F0003,共4页Journal of China-Japan Friendship Hospital

摘　　要：目的:探讨泛素降解途径蛋白Skp2和p27kip1在前列腺癌中的表达及与前列腺癌各项临床病理特征的关系,并探讨两者的相关性。方法:应用免疫组织化学法和图像分析系统研究41例前列腺癌标本、20例开放手术切除良性前列腺增生标本中Skp2和p27kip1的表达情况。分析临床病理资料与免疫组化的结果及Skp2、p27kip1之间的相关性。结果:在前列腺癌中的Skp2蛋白染色阳性率显著高于良性前列腺增生(P<0.01);前列腺癌中的p27kip1蛋白染色阳性率显著低于良性前列腺增生(P<0.01)。Skp2蛋白表达与前列腺癌术前前列腺特异性抗原(PSA)水平、肿瘤穿透前列腺被膜、肿瘤分期、病理分级均显著相关(均P<0.05)。p27kip1蛋白表达与上述临床病理特征负相关(均P<0.05)。Skp2和p27kip1蛋白表达呈负相关(r=-0.572,P<0.01)。结论:Skp2蛋白在前列腺癌中表达增加,其参与了前列腺癌的发病过程。Skp2蛋白表达与p27kip1蛋白表达之间负相关。Skp2可能成为前列腺癌治疗的一个新的靶标。Objective：To investigate the correlation between Skp2 and p27^kip1 protein expression and the clinicopathological features of prostatic carcinoma,and study the relationships between them.Methods：Skp2 and p27^kip1 protein expression were evaluated in the tissues of 41 human prostatic carcinomas as well as 20 benign prostatic hyperplasia（BPH）using immunohistochemistry.Results：The Skp2 labeling frequency in prostatic carcinoma was significantly higher than that in BPH（P〈0.01）.The p27^kip1 labeling frequency in prostatic carcinoma was significantly lower than that in BPH （P〈0.01）. The Skp2 protein expression in prostatic carcinoma was positively correlated with preoperative serum prostate-specific antigen level,extraprostatic extension,clinical stage and histological grade（P〈0.05）.The p27^kip1 protein expression in prostatic carcinoma were inversely correlated with preoperative serum prostate-specific antigen level,extraprostatic extension,clinical stage and histological grade（P〈0.05）.Conclusion：Expression of Skp2 protein may lead to decrease in level of p27^kip1 in human prostatic carcinoma,indicating its involvement in the development of human prostatic carcinoma.In addition,Skp2 may be a new target for the treatment of prostate cancer.

关 键 词：前列腺癌 SKP2蛋白 P27^KIP1蛋白 

分 类 号：R737.25[医药卫生—肿瘤]