胰岛素聚β-羟基丁酸酯微球制备工艺的研究  

Study on Preparation Technology of Insulin-Poly(β-hydroxybutyrate)Microspheres

作　　者：庞伟 杨红[2] 陆彬[2] 

机构地区：[1]甘孜藏族自治州藏医院,四川康定626000 [2]四川大学华西药学院

出　　处：《中国药师》2008年第6期613-617,共5页China Pharmacist

基　　金：国家教委博士点基金项目(编号9504113)

摘　　要：目的:以生物降解材料聚β-羟基丁酸酯(PHB)为载体材料制备胰岛素微球。方法:采用液中干燥法制备,并通过均匀设计法和星点设计法来优化其制备工艺,经差示扫描量热分析(DSC)进行物相验证。结果:微球的DSC图谱中仅有PHB的峰,而胰岛素的特征峰消失。结论:证明形成了胰岛素聚β-羟基丁酸酯微球。Objective： To prepare insulin microspheres with biodegradable poly （[3-hydroxybutyrate） as the material. Method： The microspheres were prepared by in-liquid drying method and the uniform design and central composite design were used to optimize the preparation technology. The differential scanning calorimetry was used to identify the material phase. Result： In the diagrams of differential scanning calorimetry, the characteristic peak of insulin disappeared and only that of poly（β-hydroxybutyrate） remained. Conclusion： The results showed that the insulin-poly（β-hydroxybutyrate） microspheres were formed.

关 键 词：胰岛素 聚Β-羟基丁酸酯 微球 液中干燥法 均匀设计法 星点设计法 

分 类 号：R944.9[医药卫生—药剂学]