胰岛素抵抗与非酒精性脂肪肝的关系研究  

The study of the relationship between insulin resistance and nonalcoholic fatty liver disease

作　　者：李运红[1] 徐肇敏[1] 吕瑛[1] 黄群[1] 邹晓平[1] 

机构地区：[1]南京大学医学院附属鼓楼医院消化科,江苏南京210008

出　　处：《南京医科大学学报（自然科学版）》2008年第6期787-789,共3页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省自然科学基金资助(BK2003009)

摘　　要：目的:研究胰岛素抵抗与非酒精性脂肪肝发病之间的关系。方法:连续观察体检人群81例,其中非酒精性脂肪肝患者59例,测身高、体重、腰围、臀围,计算体质指数(BMI)及腰臀比(WHR),检测空腹血清血糖、胰岛素、总胆固醇、甘油三酯,比较2组人群之间的差异。结果:非酒精性脂肪肝组较对照组BMI、WHR及血甘油三脂更高、胰岛素敏感指数更低,多元Logistic回归分析显示:对非酒精性脂肪肝的发病具有影响的是WHR和胰岛素敏感指数。结论:WHR和胰岛素敏感指数是非酒精性脂肪肝发病的独立影响因素。Objective：To study the relationship between insulin resistance and NAFLD. Methods：The age,BMI,WHR,TRIG,TC,and insulin sensitive index（ISI） were studied in NAFLD group and the control group. Results：The BMI,WHR,TRIG were higher in NAFLD than in the control,while the ISI was lower in NAFLD than in the control. The Logistic analysis show that WHR and ISI are important factors in the pathogenesis of NAFLD. Conclusion：WHR and ISI are the independent influential factors in the pathogenesis of NAFLD.

关 键 词：胰岛素抵抗 非酒精性脂肪肝 体质指数 腰臀比 

分 类 号：R575.5[医药卫生—消化系统]