TRPV1阻断剂的研究进展  

Progress in vanilloid receptor 1 antagonist

作　　者：王乐[1] 曹宇[1] 

机构地区：[1]中国医科大学基础医学院生理学教研室,沈阳110001

出　　处：《国际病理科学与临床杂志》2008年第3期220-224,共5页Journal of International Pathology and Clinical Medicine

基　　金：高等学校博士学科点专项科研基金(2006159004)~~

摘　　要：瞬时感受器电位香草酸受体1(TRPV1)是瞬时感受器电位(transient receptor potential,TRP)的非选择性阳离子通道蛋白家族成员之一,主要表达在初级传入感觉神经元上,是一种非选择性的阳离子通道。该受体可探测和整合诱发痛觉的化学和热刺激信号,主要有辣椒素(红辣椒的辛辣成分),伤害性热(>43℃)和质子等。它可将化学、机械和热刺激信号转化为动作电位,并将这些信息上传到中枢,最后使机体产生痛觉或不舒服的感受。近年来,TRPV1通道蛋白已成为开发新的镇痛药物的重要靶点。Transient receptor potential vanilloid 1 （ TRPV1 ） is a member of the family of transient receptor potential channels, whose expression is largely associated with primary afferent fibers. This receptor is a transducing thermal and inflammatory pain. It is activated by capsaicin （the pungent ingredient of hot peppers）, noxious heat （ 〉 43 ℃ ） and proton, then transmits this information to the central nervous system, ultimately eliciting a perception of pain or discomfort. Recently, TRPV1 has been a new target against pain and attentions have been paid to its antagonists for the pain relief.

关 键 词：瞬时感受器电位香草酸受体1 辣椒素 热 疼痛 阻断剂 

分 类 号：R971[医药卫生—药品]