炎症性肠病与骨代谢研究若干进展  

Advances of bone metabolism disease in inflammatory bowel disease

作　　者：张文燕[1] 袁耀宗[1] 

机构地区：[1]上海交通大学附属瑞金医院消化科,200025

出　　处：《国际消化病杂志》2008年第3期217-219,共3页International Journal of Digestive Diseases

摘　　要：骨质疏松(OP)是炎症性肠病(IBD)患者常见但易被忽视的并发症之一。IBD患者骨代谢异常的发病机制除了营养不良,钙、磷吸收异常,性腺功能减退之外,还与使用激素,炎症因子的异常活化等紧密相关。研究发现IBD患者骨质疏松发生率在15%左右,在老年IBD患者身上表现尤为显著,使用激素是其主要危险因子。IBD患者骨折发生率并没有原先预期的那么高。骨代谢指标对预测IBD患者BMD及骨折发生价值有限。Osteoporosis is one of the complications of inflammatory bowel disease（IBD）, which is easy to be ignored. Except for corticosteroid use and the activation of pro-inflammatory cytokines, the pathogenesis of IBD-induced osteoporosis includes malnutrition, calcium and phosphonium malabsorption, hypoganadism et al. The prevalence of osteoporosis in inflammatory bowel disease is about 15%, with osteoporosis more common in older subjects. The main risk factor is corticosteroid use . The overall incidence of fractures in inflammatory bowel disease is not higher than expected. Biochemical bone markers do not correlate sufficiently well with current BMD or rate of bone loss.

关 键 词：炎症性肠病 骨质疏松 发病率 骨折风险 

分 类 号：R574[医药卫生—消化系统] R587.2[医药卫生—内科学]