中国女性乳腺癌危险因素的Meta分析  

Meta-analysis on the risk factors of breast cancer among Chinese female

作　　者：裴广军[1] 付莉 崔亚玲[3] 王文雷[1] 高利华[1] 陆维权[3] 

机构地区：[1]郑州大学公共卫生学院,河南郑州450001 [2]河南省职工医学院 [3]河南省肿瘤研究所

出　　处：《中国妇幼保健》2008年第19期2650-2652,共3页Maternal and Child Health Care of China

摘　　要：目的:评价中国女性乳腺癌部分危险因素的作用,探索乳腺癌的病因。方法:运用Meta分析方法对我国1996～2006年间公开发表的有关乳腺癌危险因素病例对照研究的12篇文献资料进行定量综合分析。结果:各因素合并OR值分别为:初潮年龄(年)OR=1.54(95%CI:1.3437～1.7654);哺乳OR=0.68(95%CI:0.4779～0.9782);口服避孕药OR=1.33(95%CI:1.0627～1.6589);良性乳腺疾病史OR=2.62(95%CI:2.0275～3.3804);吸烟OR=1.86(95%CI:1.5394～2.2415);饮酒OR=0.81(95%CI:0.6196～1.0686);饮茶OR=0.86(95%CI:0.7646～0.9728)。结论:初潮年龄、口服避孕药、良性乳腺疾病史及吸烟是乳腺癌发生的危险因素,哺乳及饮茶则是乳腺癌的保护因素。Objective：To study the breast cancer＇s pathogenesis through appraising the main risk factors related to the incidence of breast cancer among Chinese female.Methods：The results from 12 literature about case-control studies on risk factors of breast cancer from 1996 to 2006 were analyzed quantitatively and synthetically by Meta-analysis.Results：The pooled odds ratio values were：age at menarche（y）OR=1.54（95%CI：1.343 7-1.765 4）;Breast-feeding OR=0.68（95%CI：0.477 9-0.978 2）;Oral-contraceptive use OR=1.33（95%CI：1.062 7-1.658 9）;History of benign breast diseases OR=2.62（95%CI：2.0275-3.3804）;Smoking OR=1.86（95%CI：1.539 4-2.241 5）;Alcohol drinking OR=0.81（95%CI：0.619 6-1.068 6）;Tea drinking OR=0.86（95%CI：0.7646-0.9728）.Conclusion：The risk factors influencing the incidence of breast cancer among Chinese female are age at menarche（y）,oral-contraceptive use,history of benign breast diseases and smoking;The protective factors are breast-feeding and tea drinking.

关 键 词：乳腺癌 病例对照 危险因素 META分析 

分 类 号：R737.9[医药卫生—肿瘤]