黄芩茎叶总黄酮对大鼠气囊滑膜炎抗炎作用机制的研究  

Mechanism of Anti-aerocyst Arthromeningitis Effect of Total Flavonoids of Baical Skullcap Stem and Leaf

作　　者：王玮[1] 白月[2] 王俊平[1] 

机构地区：[1]沈阳医学院基础医学院药理学教研室,辽宁沈阳110034 [2]辽宁省人民医院检验科

出　　处：《沈阳医学院学报》2008年第1期24-25,共2页Journal of Shenyang Medical College

基　　金：沈阳医学院青年基金项目(No.200420)

摘　　要：目的:研究黄芩茎叶总黄酮的抗炎机制。方法:制作大鼠气囊滑膜炎模型,测定各组大鼠炎性渗出物中蛋白质总量。采用酶联免疫分析方法,定量检测白三烯(LTB4)的生成量。结果:黄芩茎叶总黄酮组可明显抑制炎性渗出物中蛋白质及LTB4的生成。结论:黄芩茎叶总黄酮的抗炎作用机制与抑制5-脂氧合酶活性有关。Objective：To study the mechanism of the anti-aerocyst arthromeningitis effect of total flavonoids of Baical Skullcap Stem and Leaf. Methods：Rat model of aerocyst arthromeningitis was made and the total proteins and leukotriene B4 in the rat inflammatory exudates using enzyme-linked immuno assay were determined. Results ： Total flavonoids of Baical Skullcap Stem and Leaf could effectively inhibit the formation of LTB4 in polymorphonuclear leucocytes. Conclusion： Its anti-inflammatory action might be resulted from its inhibition of 5-lipoxygenase.

关 键 词：黄芩茎叶总黄酮 抗炎 蛋白质总量 白三烯B4 

分 类 号：R743[医药卫生—神经病学与精神病学]