泰脂安对高胆固醇血症兔血脂和主动脉内膜中巨噬细胞的影响  

Effects of Taizhian treatment on the macrophages in the plague of aotic intima and the levels of blood lipid in hypercholesterolemic rabbits

作　　者：段书[1] 邓平[1] 赵水平[1] 梁青春[1] 

机构地区：[1]中南大学湘雅二医院心血管内科,湖南长沙410011

出　　处：《中华老年医学杂志》2008年第6期471-473,共3页Chinese Journal of Geriatrics

摘　　要：目的观察泰脂安对高胆固醇血症兔血脂和主动脉内膜中巨噬细胞的影响，以探讨泰脂安在调脂和抗动脉粥样硬化中的作用。方法给16只新西兰健康雄兔高胆固醇饮食，8周后随机给予泰脂安1.0g·kg^-1·d^-1，8只为泰脂安组；淀粉干预25.0mg·kg^-1·d^-1，8只为对照组；另8只兔每天分别进食普通饲料120g（正常饮食组）。6周后测定血清血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-c），采用免疫组织化学法测定主动脉内膜中巨噬细胞阳性数。结果与正常饮食组比较，对照组和泰脂安组Tc[分别为（1.8±0.7）mmol／L与（27.8±1.0）mmol／L和（26.5±2.5）mmol／L]、LDL-c[（0.6±0.2）mmol／L与（14.5±3.3）mmol／L和（13.7±4．1）mmol／L]升高，均为P〈0.05。经泰脂安干预后，主动脉粥样硬化斑块中巨噬细胞表达下降[（71．8±15．5）％与（53．8±12．7）％，P〈0.05]；Tc[（19.0±4.3）mmol／L]和LDL-c[（11．6±2．2）mmol／L]水平下降（P〈0.05）。结论泰脂安能有效地调节血脂和降低动脉粥样硬化程度。Objective To observe the effects of Taizhian treatment on macrophages expression in the plaque of aotic intima and blood lipid levels in hypercholesterolemic rabbits. Methods Sixteen male New Zealand rabbits were given 1% high-cholesterol diet. After 8 weeks, these hypercholesterolemic rabbits were switched to receiving either Taizhian 1.0g·kg^-1·d^-1（n= 8） or starch 25.0mg·kg^-1·d^-1（n=8）. Six weeks later, the levels of blood lipid were determined, and macrophages expression in aotic intima was detected by immunohistochemistry. Results Compared with normal rabbits, Taizhian treatment decreased the expression of macrophages in aortic intima by 25% and reduced serum levels of low density lipoproteiwcholesterol by 21% in hypercholesterolemic rabbits（both P〈0.05）. Conclusions Taizhian may significantly decrease blood lipid level and reduce atherosclerosis in hypercholesterolemic rabbits.

关 键 词：女贞属 高胆固醇血症 膳食 致动脉粥样化 

分 类 号：R686[医药卫生—骨科学]