PIG7基因与疾病  

PIG7 gene and human diseases

作　　者：刘家卓[1] 王建祥[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所血液病医院实验血液学国家重点实验室,天津300020

出　　处：《基础医学与临床》2008年第6期642-645,共4页Basic and Clinical Medicine

摘　　要：P53分子介导的凋亡途径是细胞内重要的信号整合机制,通过识别细胞损伤启动下游促凋亡信号。PIG7是与P53诱导凋亡密切相关的基因,与代谢、炎症、肿瘤等关系紧密,逐渐成为近年相关领域的研究热点。本文从PIG7基因的发现、生物学功能及与人类疾病的关系等方面对该基因的研究进展予以综述。Apoptosis induced by P53 gene is one of the most important mechanisms of signal integration in ceils, which identify the cell injury and start downstream apoptotic signals. PIG7 gene is induced by P53 and correlates with metabolism, inflammation and tumor occurence. Here we reviewed the recent findings in the molecular biology of PIG7 gene and the correlation with human diseases.

关 键 词：PIG7 LITAF SIMPLE Charcot—Marie—Tooth病 炎性肠病 肿瘤 

分 类 号：R363[医药卫生—病理学]