PTEN在维护基因组稳定性中的作用  

The Effect of PTEN on Genetic Stability

作　　者：陈忠民[1] 霍艳英[1] 吴德昌[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京市100850

出　　处：《医学分子生物学杂志》2008年第3期247-250,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金(No.30770652)~~

摘　　要：最新研究发现,具有磷酸酶活性的肿瘤抑制基因pten在维持染色质和基因组稳定性方面起着重要的作用。PTEN可以磷酸酶依赖型和非依赖型两种方式维护基因组的稳定性。PTEN的磷酸酶依赖型调控机制主要通过PI3K/AKT通路;PTEN的磷酸酶非依赖型调控机制主要通过蛋白质的相互作用;此外还存在一些未知的途径。It is recently reported that tumor suppressor pten, encoding a protein and lipid phosphatase, plays a critical role in maintaining chromosomal integrity and genetic stability through phosphatase-dependent pathway as well as phosphatase-independent pathway. The mechanism of phosphatase-dependent pathway works mainly via PI3K/AKT way and the mechanism of phosphatase-independent pathway is mainly via interaction between proteins. In addition, there are still some pathways which have not been identified.

关 键 词：PTEN 基因组不稳定性 

分 类 号：R349.64[医药卫生—基础医学]