白血病血清溶血活性的临床意义  

CLINICAL SIGNIFICANCE OF HEMOLYTIC ACTIVITY IN LEUKEMIA SERA

作　　者：郭辉[1] 朱爱英[1] 李玉秀[1] 尹济群[2] 姚尔固[1] 

机构地区：[1]河北医学院附属二院血液病研究室 [2]河北医学院附属二院检验科

出　　处：《河北医学院学报》1990年第3期148-150,共3页

摘　　要：白血病中有血清溶血因子能使正常人红细胞膜变异,通过经典途径被补体激活,在蔗糖及低离子强度条件下引起溶血。作者利用逆蔗糖溶血试验(ISHT),观察50例白血病人血清的溶血活性,发现疾病的活动期55.6％ISHT阳性。疾病活动期溶血活性明显高于疾病完全缓解期或部分缓解期;也发现溶血活性与病情相关良好,随病情好转而降低复发而增高,而且可在其它血液参加提示复发前出现。作者认为ISHT是观察疾病活动性及治疗效果的简单、重复性好的指标。ABSTRACT Hemolytic factors in leukemia sera are able to induce modification of the membrane of normal human erythrocytes, resulting in cell lysisthrough the classical pathway activation of complement in the presence of sucrose at low ionic strength. The hemolytic activity in serum samples from 50 patients with leukemia was investigated by inverse sucrose hemolytic test(ISHT). ISHT was positive in 55. 6% samples collected during active stage of disease. The hemolytic activity in sera of active disase stage was markedly higher than that in sera from complete or partial remission. The hemolytic activity correlated well with condition of discuse, reducing with the improvement of disease and increasing with leukemia relapse and might occur before any sign of relapse disclosed by other hematologic parameters. We conclude that ISHT is a simple and reproduceable indicator in monitoring disease activity and in predicting the therapeutic results.

关 键 词：白血病 血清 溶血活性 ISHT 

分 类 号：R733.702[医药卫生—肿瘤]