硝喹对约氏疟原虫红内期细胞色素氧化酶的影响  

EFFECTS OF NITROQUINE ON CYTOCHROME OXIDASE IN ERYTHROCYTIC STAGE OF PLASMODIUM YOELII YOELII

作　　者：陈晓红[1] 胡友梅[1] 廖雅琴[1] 张文军[1] 柯金星[1] 

机构地区：[1]第三军医大学药理教研室,第三军医大学中心仪器室

出　　处：《动物学报》1997年第4期353-355,共3页ACTA ZOOLOGICA SINICA

基　　金：国家自然科学基金

摘　　要：给感染约氏疟原虫的小鼠，灌服硝喹（２ｍｇ／ｋｇ）后，用细胞色素氧化酶组织化学方法处理红细胞，透射电镜观察疟原虫。结果发现，约氏疟原虫红内期线粒体内存在细胞色素氧化酶，硝喹不能抑制该酶的活性。说明约氏疟原虫内细胞色素氧化酶不是硝喹的起始作用点。Mice infected with Plasmodium yoelii yoelii were treated with nitroquine(NQ) 2mg/kg per os.After 35h,7h,14h,blood was taken and incubated by cytochrome oxidase histochemical method.Mitochondria of Plasmodium yoelii yoelii were observed with transmitt electron microscope. It was found that there is cytochrome oxidase in erythrocytic stage of Plasmodium yoelii yoelii, and its activity was not inhibited by NQ.These results showed that there is TCA cycle in erythrocytic Plasmodium yoelii yoelii and cytochrome oxidase was not the beginning point of action by NQ.

关 键 词：细胞色素氧化酶 硝喹 约氏疟原虫 红内期 药理学 

分 类 号：R978.61[医药卫生—药品] R382.31[医药卫生—药学]