大肠癌增殖细胞核抗原的表达与淋巴结转移关系  

The correlations between PCNA expression and nodal metastasis in colorectal carcinoma

作　　者：吴建农[1,2] 王懿龄[1,2] 

机构地区：[1]镇江医学院附属医院病理科 [2]上海医科大学肿瘤医院病理科

出　　处：《临床与实验病理学杂志》1997年第3期244-245,共2页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的：探讨大肠癌增殖细胞核抗原（ＰＣＮＡ）表达与淋巴结转移关系。方法：用免疫组织化学ＡＢＣ法研究１１９例大肠癌肿瘤组织内ＰＣＮＡ的表达。结果：肿瘤细胞ＰＣＮＡ阳性率较高的病例淋巴结转移率也较高，说明ＰＣＮＡ阳性率较高的肿瘤细胞生长速度较快，易发生淋巴结转移，预后较差。结论：肿瘤细胞ＰＣＮＡ的表达可以作为判断肿瘤预后的一个客观标志。Purpose To examine the relationship between the expression of proliferating cell nuclear antigen (PCNA) and nodal metastasis in colorectal carcinoma. Methods The PCNA expression in 119 cases of colorectal carcinoma was analysed with ABC immunohistochemical method. Results The tumor cells which were high in PCNA positivity had a powerful ability in proliferation and were easy to infiltrate into lymphoduct to metastasize. Conclusions The expression of PCNA in tumor cells is an objective indicator to predict the prognosis.

关 键 词：增殖细胞核抗原 淋巴结转移 大肠肿瘤 

分 类 号：R735.34[医药卫生—肿瘤]