硫普罗宁的合成工艺研究  

Study on Synthesis of Tiopronin

作　　者：王哲[1] 王佶[1] 陈笑宇[1] 许佑君[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016

出　　处：《当代化工》2008年第3期241-242,共2页Contemporary Chemical Industry

摘　　要：以廉价易得的2-溴丙酸为起始原料,依次经过氯代,缩合,亲核取代及脱保护反应制备了硫普罗宁,总收率为35.7%。其中取代反应和脱保护反应用"一锅法"完成,较原工艺缩短了生产周期,提高了反应收率,同时减少了"三废"排放,降低了生产成本。Starting from 2-bromopropionic acid,tiopronin was synthesized via chloronation,condensation,nucleophilic substitution and deprotection,and the total yield was 47.9 %. Nucleophilic substitution and deprotection were carried out in ＂one-pot＂, so production cycle was shortened, the reaction yield was increased, at the same time the discharge of＂three industrial wastes＂ was decreased, the cost of production was reduced.

关 键 词：硫普罗宁 合成 工艺优化 一锅法 

分 类 号：TQ245[化学工程—有机化工]