运用功率谱分析预测基因组序列编码区  

Prediction of Coding-Region in Genomic Sequences Based on Power Spectrum Analysis

作　　者：王玉[1] 熊莉英[1] 

机构地区：[1]西南科技大学信息工程学院,四川绵阳621010

出　　处：《西南科技大学学报》2008年第2期84-87,共4页Journal of Southwest University of Science and Technology

基　　金：西南科技大学青年基金(NO.07ZX3108)

摘　　要：基因组序列中蛋白编码区的正确预测是后基因组时代的一个重要工作。采用分解子序列的方法将DNA序列映射为数值序列,然后对其进行功率谱分析,DNA序列的功率谱曲线的峰值位置刚好和编码区序列相对应,从而实现了对基因组序列编码区的预测。理论分析和大量计算机实验证实了方法的有效性,预测的探测率和正确率分别达到97%和88%,预测效果良好。该方法不需要基因组序列的任何先验知识,应用面广。Identification of gene is one of the most important work in postgenome era. In this paper, DNA sequences were converted to four binary sequences, then it was analyzed by power spectrum analysis, the peaks of the power spectrum curve were exactly biunique with protein-coding region. Thereby the proteincoding region can be identified. Theoretical analysis and experiment result show that the method is excellent for predicting coding-region of genomic sequences, the sensitivity and the specificity of the reach 97% and 88%. No priori knowledge of the genome sequences is required of the method, thus find general application.

关 键 词：功率谱分析 基因组序列 蛋白编码区 

分 类 号：Q811.4[生物学—生物工程]