乳香挥发油脂质体处方及制备工艺的研究  

Formula and technology of liposomes of boswellia carterii birdwood volatile oil

作　　者：刘让如[1] 谭桂山[2] 徐康平[2] 贺凌云[2] 

机构地区：[1]海南医学院药学系,海南海口571101 [2]中南大学药学院,湖南长沙410013

出　　处：《海南医学院学报》2008年第4期319-321,共3页Journal of Hainan Medical University

摘　　要：目的:对乳香挥发油脂质体的处方及制备工艺进行研究。方法:先采用单因素考察,选取出对脂质体包封率影响较大的因素和水平,再以包封率为考核指标进行正交试验,筛选出最佳的处方和工艺组合。结果:各因素最佳的水平组合为:胆固醇与磷脂的重量比为1∶6、药脂重量比为1∶6、制备温度为60℃。结论:验证3批脂质体样品的平均包封率为(82.4±1.5)%,所制得的乳香挥发油脂质体包封率稳定,筛选出了乳香挥发油脂质体最佳的处方及工艺组合。Objective： To study the formula and technology of preparation of liposomes of boswellia carterii birdwood volatile oil （BCBV）. Methods： Single -factor study was conducted at first to find out major factors related to the encapsulation of liposomes of BCBV; then by the efficiency of encapsulating of liposomes of BCBV, using orthogonal design method to screen out an optimal integration of formula and technology. Results ： The opti- mal formula and technique ： Ratio of cholesterol and lecithin was 1：6, ratio of drug and lecithin was 1：6, the temperature of the preparation was 60 ℃. Conclusion： The average encapsulating rate of the optimized liposomes of BCBV in 3 batches of samples was （82.4 ±1.5） % , which was stable in preparation ; the ideal formula and technology of preparation of liposomes of BCBV was obtained.

关 键 词：乳香属 脂质体 处方 非药物 工艺学 

分 类 号：TQ644.1[化学工程—精细化工]