2-羟基查耳酮的合成工艺研究  

Study on synthesis of 2-hydroxyl chalcon

作　　者：苗彩霞[1] 洪镛裕[1] 邓优华[1] 

机构地区：[1]华东师范大学化学系,上海200062

出　　处：《化学试剂》2008年第1期63-64,共2页Chemical Reagents

摘　　要：查耳酮类化合物是合成黄酮类化合物重要的中间体,具有重要的药理作用。研究了在稀碱催化下邻羟基苯乙酮和苯甲醛在乙醇溶液中的羟醛缩合反应,溶剂可以循环使用,适合工业化生产。Chalcon is an important intermediate for synthesizing flavons, and has been associated with a wide variety of pharmaceutical activities. In the presence of ethanol, the condensation of 2-hydroxyl acetophenone and benzadehyde was catalyzed by a dilute sodium hydroxide solution with good yields under mild condition. Also, the ethanol solvent could be recycled. This route is suitable for commercial production.

关 键 词：查耳酮 黄酮类化合物 循环使用 工业化生产 

分 类 号：O625.43[理学—有机化学]