银杏叶提取物对大鼠学习记忆能力的影响  

EFFECTS OF GINKGO BILOBA EXTRACT ON LEARNING AND MEMORY ABILITY OF RATS WITH VASCULAR DEMENTIA

作　　者：吴禹[1] 胡长林[1] 

机构地区：[1]重庆医科大学附属第一医院,重庆400010

出　　处：《现代预防医学》2008年第13期2585-2586,共2页Modern Preventive Medicine

摘　　要：[目的]探讨银杏叶提取物对血管性痴呆大鼠学习记忆能力的影响。[方法]建立血管痴呆动物模型。术后2周通过明暗箱避暗回避实验测试其学习记忆能力和测定脑组织匀浆超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力和丙二醛(MDA)含量,同时观察海马CA1区病理组织学变化。[结果]与假手术组比较,模型组大鼠避暗实验错误次数增多,潜伏期延长,大鼠脑组织的SOD和GSH-Px活力降低,MDA含量增高,其差异有显著性。与模型组比较,治疗组大鼠避暗实验错误次数减少,潜伏期缩短,大鼠脑组织的SOD和GSH-Px活力增高,MDA含量降低,脑组织病理改变较模型组轻,其差异有显著性。[结论]银杏叶提取物可增强缺血脑组织SOD和GSH-Px活力,降低MDA含量,清除氧自由基,抑制神经细胞凋亡,改善血管性痴呆大鼠学习记忆能力。[ Objective ] To investigate effects of ginkgo biloba extract （GBE） on learning and memory ability of rats with vascular dementia. [ Methods] Rats＇ model of vascular dementia was established. Sham-operation group and operation group were administered normal saline. GBE group was administered ginkgo biloba extract. The superoxide dismutase （SOD）, glutathion peroxidase （GSH-Px） activities and the malondialdehyde （MDA） content in the cerebral tissue were detected after 14 days. Meanwhile the neurons of the hippocampal CA1 was obsenved. [ Results] The SOD and GSH-Px activities in the GBE group increased, while the MDA content significantly decreased comparing with the those in operation group （P 〈 0.05）. The results indicated that the pathological changes in the GBE group were slighter than those in the operation group. [ Conclusion] Ginkgo biloba extract on rats with vascular dementia could enhance SOD and GSH-Px activities, decrease the MDA content, then protect nerve cells from apoptosis.

关 键 词：银杏叶提取物 血管性痴呆 大鼠 学习记忆 

分 类 号：R743[医药卫生—神经病学与精神病学]