丙型肝炎病毒和乙型肝炎病毒重叠感染对肝细胞癌的影响  

THE EFFECT OF HEPATITIS C VIRUS AND HEPATITIS B VIRUS CO－INFECTION ON HEPATOCELLULAR CARCINOMA

作　　者：吴健[1] 郑树森[1] 范俊[2] 马伟杭[2] 

机构地区：[1]浙江医科大学附属第一医院肝胆外科,310003 [2]浙江医科大学附属第一医院病毒室

出　　处：《中国现代医学杂志》1997年第12期19-20,23,共3页China Journal of Modern Medicine

摘　　要：运用巢式聚合酶链反应（nested－PCR）检测36例经外科手术治疗的肝细胞癌（HCC）患者的肝癌组织或癌周组织中的丙型肝炎病毒（HCV）RNA，并检测血清中的乙型肝炎病毒（HBV）表面抗原来显示HCC患者中HCV和HBV的感染情况，同时收集一般临床资料。结果表明36例HCC患者中，HCV感染者13例（36．1％）．HBV感染者30例（83．3％），两者重叠感染者12例（33．3％），并发现HCV、HBV重叠感染者较仅HBV感染者肝癌直径较大，血清ALT平均值较高，术后1年生存率较差；而在发病年龄，血清AKP、AFP阳性率等方面均无差别，提示HCV、HBV重叠感染可加速肝癌发展，手术预后较差。To identify Hepatitis C Virus (HCV) and/or Hepatitis B Virus (HBV) infection in hepatocellular carcinoma(HCC) patients, HCV － RNA was detected by nested polymerase chain reaction (PCR) in liver cancer or para－can－cer tissue. The tissuc was taken from 36 HCC patients who were surglcally treated and in whom the HBV surfaceantigcn was detected in scra. All of the clinical data were collected at the were collected al the same time. The results show 13 patientssuffering from HCV infection (36. 1 % ), 30 cascs of HBV infectionn (83. 3% ), and 12 cases with HCV and HBVco－infection (33. 3 % ). The tumor diameter is larger, serum ALT value is higher, and one year post－operative survival rate is lower in those patients with HCV and HBV co－intection than in those with only HBV infection . However, there were no differences noted in mobility age, AKP value, and AFP positive rate. The results suggest thatHCB and HBV co－infection can accelerate the development of HCV and the post－operative prognosis is poor.

关 键 词：肝细胞癌 丙型肝炎病毒 乙型肝炎病毒 肝肿瘤 

分 类 号：R735.702[医药卫生—肿瘤] R373.2[医药卫生—临床医学]