毒品成瘾与脑组织基因表达谱的研究进展  

Gene expression profiling in drug addicted brain

作　　者：陈峰[1] 李涛[1] 樊栓良[1] 党永辉[1] 陈腾[1] 阎春霞[1] 

机构地区：[1]西安交通大学医学院法医学系、卫生部法医学重点实验室、环境与疾病相关基因教育部重点实验室,西安710061

出　　处：《遗传》2008年第7期809-814,共6页Hereditas（Beijing)

基　　金：国家自然科学基金资助项目(No.30672356,30572089);陕西省社会发展科技攻关项目(No.2006K08-G6)~~

摘　　要：毒品成瘾是由滥用毒品外在因素与遗传易感性等内在因素共同作用而导致的一种慢性脑疾病;毒品成瘾的机制目前还不十分清楚。毒品成瘾研究的一个主要目标是鉴别和分离毒品导致脑功能障碍的分子机制;采用高通量的基因表达谱技术研究毒品成瘾者在不同状态下脑基因表达全貌,对深入认识毒品成瘾的机制具有重要的意义。文章综述了毒品成瘾的遗传机制及高通量脑组织基因组表达技术——SAGE和微阵列(Microarry)在毒品成瘾研究中的进展。Drug addiction, a chronic brain disease caused by interaction of in vitro drug toxification and in vivo gene susceptibility, has been widely studied but its underlining mechanism is so far been elucidated. A major goal in this field is to identify drug-induced molecular changes and their effects on brain function. By the advance of high throughput technologies in genomics and transcriptomics, the whole gene expression profile in addicted brain could be obtained and proved to be a very powerful tool to unclose the molecular mechanism underlying the addiction biology context. Here, we summarized the progress of serial analysis of gene expression （SAGE） and microarray, as well as their application in drug addiction.

关 键 词：毒品滥用 毒品成瘾 基因表达谱 基因表达系列分析(SAGE) 微阵列 生物信息学 

分 类 号：R749.64[医药卫生—神经病学与精神病学]