生长激素对术后早期腹腔化疗下结肠吻合口愈合的影响  

Effect of growth hormone on the healing of colon anastomoses during early postoperative intraperitoneal chemotherapy

作　　者：张松岩[1] 曲宏岩[1] 

机构地区：[1]哈尔滨医科大学第三临床医学院腹外科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2008年第3期271-273,共3页Journal of Harbin Medical University

摘　　要：目的研究应用生长激素(GH)对术后早期腹腔化疗条件下结肠吻合口愈合的影响。方法Wistar大鼠60只,随机分为3组:对照组,单纯行肠切除吻合;术后早期腹腔化疗组(5-Fu组),术后连续3天腹腔内注射氟尿嘧啶(5-Fu)20 mg/(kg.d);GH组,术后给予生长激素1 mg/(kg.d)7天及术后早期腹腔化疗。术后8天处死各组大鼠,剖腹切取吻合口测量吻合口评分(评分越高提示吻合口与周围组织的粘连越重)和测量吻合口破裂压力及进行吻合口组织学评分。结果GH组的吻合口评分2.00,低于对照组(2.38),但P>0.05,差异无统计学意义。GH组显著低于5-Fu组的2.75,P<0.05;差异有统计学意义。GH组的吻合口破裂压力229.95,高于对照组(199.75),P<0.05;显著高于5-Fu组(171.79),P<0.01。GH组的吻合口组织学评分2.9,高于对照组(2.1)及5-Fu组(1.7),P<0.05。结论应用生长激素能提高吻合口愈合强度,促进术后早期腹腔化疗条件下结肠吻合口愈合。Objective To investigate the effect of growth hormone on the healing of colon anastomoses after early postoperative intraperitoneal chemotherapy. Methods Sixty rats were randomized into 3 groups ： control group：only colon resection and sutured anastomosis was performed;early postoperative intraperitoneal chemo-therapy（EPIC） group：5-Fu 20 mg/（kg·d） was injected intraperitoneally for 3 days after the operation; growth hormone group：the EPIC was given and growth hormone 1 mg/（kg·d） was injected subcutaneously for 7 days. All the rats were killed on the 8th postoperative day to investigate the adhesion formation score, the bursting pressure, and the macroscopical examination. Results The adhesion formation score of the early postoperative intraperitoneal chemotherapy group was significantly higer than those of other groups; the bursting pressure of the growth hormone group was significantly higer than those of other groups; There was more fibroblast activity in the growth hormone group than those in other groups（ P 〈 0.05）. Conclusion Using growth hormone can improve the healing of colon anastomoses in the condition of the early postoperative intraperitoneal chemotherapy.

关 键 词：腹腔化疗 生长激素 肠吻合 

分 类 号：R730.53[医药卫生—肿瘤]