XRCC3基因多态性与汉族人群膀胱癌的相关性  

Relationship between XRCC3 gene polymorphism and bladder cancer in the Han population

作　　者：郝钢跃[1] 张月英[2] 张维东[2] 杨明山[3] 贾青[2] 

机构地区：[1]首都医科大学附属北京友谊医院泌尿外科,北京100037 [2]山东省医学科学院基础医学研究所山东现代医用药物与技术重点实验室,济南250062 [3]山东省肿瘤防治研究院泌尿外科,济南250117

出　　处：《山东大学学报（医学版）》2008年第6期612-615,共4页Journal of Shandong University:Health Sciences

基　　金：北京市自然科学基金资助项目(7052025);北京市优秀人才专向培养基金资助项目(20061D0300100064)

摘　　要：目的探讨DNA修复基因XRCC3多态性与膀胱癌危险性的关系。方法选择中国汉族人群中膀胱癌患者307例为病例组，316例非肿瘤泌尿系疾病患者为对照组，两组年龄性别构成均衡。以PCR-RFLP技术，检测病例组和对照组的XRCC3（Thr241Met）基因型，比较不同基因型与膀胱癌危险性以及膀胱癌临床特征的关系。结果XRCC3基因型Thr/Thr、Thr/Met和Met／Met在病例组的分布频率分别为87．3％、12．1％和0．6％，在对照组的分布频率为92．4％、7．3％和0．3％。与携带Thr／Thr的个体相比，携带XRCC3变异基因型（Thr／Met和Met／Met）的个体具有更高的患癌风险（OR，1．77；95％CI，1．04-3．02）。XRCC3基因型与吸烟没有交互作用，与膀胱癌的临床类型亦无相关性，但与浅表性膀胱癌的复发关系密切。携带XRCC3变异基因型的浅表性膀胱癌患者具有更高的复发风险（OR，3.08；95％CI，1．13～8．41）。结论XRCC3基因多态性与膀胱癌危险性有关，携带变异基因型的个体易患膀胱癌，而且XRCC3基因有可能成为一个预测膀胱癌复发的指标。Objective To investigate the relationship between polymorphisms of DNA repair gene XRCC3 and the risk and clinical outcome of bladder cancer. Methods In a hospital based ease-control study for the Chinese population, a total of 307 bladder cancer eases and 316 age- and sex-matched controls with urological non-neoplastic diseases were collected. We analyzed the genotypes of XRCC3 （Thr241Met） by PCR-RFLP and determined their association with bladder cancer risk and clinical outcome. Results The frequency of Thr/Thr, Thr/Met and Met/Met genotype was 87.3%, 12.1% and 0. 6% in eases and was 92.4%, 7.3% and 0.3% in controls. When Thr/Thr served as the reference group, variant genotypes （Thr/Met and Met/Met） had a significant increased risk of bladder cancer（OR, 1.77;95%CI, 1.04-3.02）. Combined with smoking and clinical types, no significant interaction could be found. However, the variant genotypes were associated with an increase of recurrence risk among superficial bladder eaneer（OR,3.08;95%CI, 1.13-8.41）. Conclusions XRCC3 gene polymorphism may be a risk factor for bladder cancer and it may serve as a molecular marker for monitoring bladder cancer recurrence.

关 键 词：多态性 限制性片段长度 膀胱肿瘤 复发 X线交错互补修复基因3 

分 类 号：R737.14[医药卫生—肿瘤] R73-31[医药卫生—临床医学]