血卟啉衍生物对大鼠移植瘤放疗的增敏作用  

THE SENSITIZING EFFECT OF HEMOTOPORPHYRIN DERIVATION(HPD) ON RADIOTHERAPY FOR TRANSPLANTED TUMOR IN MICE

作　　者：崔瑞耀[1] 邹伟[1] 沈方臻[1] 王玉贞[1] 夏冰 陈维刚[1] 

机构地区：[1]青岛医学院

出　　处：《青岛医学院学报》1997年第2期127-128,共2页Acta Academiae Medicinae Qingdao Universitatis

基　　金：山东省科委基金

摘　　要：①目的探讨血卟啉衍生物（ＨＰＤ）对恶性肿瘤放射治疗的增敏作用。②方法应用图象分析技术测定大鼠移植Ｗ２５６肿瘤单纯放射治疗组（对照组）和ＨＰＤ并放射治疗组（实验组）肿瘤细胞的ＤＮＡ含量。③结果实验组大鼠肿瘤细胞ＤＮＡ含量为５．８４±１．２２Ｃ；对照组大鼠肿瘤细胞ＤＮＡ含量为７．８３±０．６８Ｃ；两组比较差异有极显著性（ｔ＝６．３７，Ｐ＜０．０１）。④结论ＨＰＤ对放射治疗恶性肿瘤有明显的增敏作用。Objective To study the sensitizing effect of hemotoporphyrin derivation(HPD) on radiotherapy for transplanted tumor in mice. Methods DNA contents of W 256 tumor cells in both radiotherapy group(control group) and radiotherapy plus HPD group(experimental group) were measured with image analysis technique. Results DNA content of tumor cells was 5.84±1.22C in the experiment group and 7.83±0.68C in the control group. Conclusion PHD has significantly sensitizing effect on radiotherapy for malignant tumors.

关 键 词：肿瘤 血卟啉类 放射疗法 DNA 增敏作用 HPD 

分 类 号：R730.55[医药卫生—肿瘤] R73－36[医药卫生—临床医学]