环氧化酶-2在乳腺癌中的表达及与血管生成的关系  

Expression of Cyclooxygenase-2 and Its relationship with Tumor Angiogenesis in Breast Carcinoma

作　　者：庄晓明[1] 周祀侨[2] 

机构地区：[1]南京大学医学院附属鼓楼医院普外科,江苏南京210008 [2]南京大学医学院附属鼓楼医院病理科,江苏南京210008

出　　处：《医学临床研究》2008年第6期1059-1061,共3页Journal of Clinical Research

摘　　要：【目的】检测环氧化酶-2(COX-2)在乳腺癌组织中的表达,研究其与乳腺癌临床病理特征及微血管密度(MVD)、血管内皮生长因子(VEGF)之间的关系。探讨COX-2对乳腺癌血管生成的作用和意义。【方法】应用免疫组化法检测73例乳腺癌标本中COX-2、VEGF的表达和CD34标记的MVD值。【结果】73例病例中57例COX-2表达阳性,表达率为78.1%(57/73),而中度以上表达率为47.9%(35/73);COX-2表达程度与患者年龄、肿瘤直径及HER-2/neu表达程度无关(P>0.05),但与腋淋巴结转移状况和肿瘤分期有关(P<0.01);COX-2表达程度与VEGF表达程度及MVD值明显相关,高表达组的MVD明显高于低表达组,两组差异有显著性(P<0.01)。【结论】COX-2能促进乳腺癌新生血管的形成,进而影响乳腺癌的发展和转归。[Objective] To detect the expression of cyclooxygenase-2 （COX-2） in breast carcinoma tissue and to investigate the relationship between its expression level and the microvessel density（MVD）, vascular endothelial growth factor（VEGF） and other clinicopathologic parameters of the object tissue. [Methods]The samples from 73 patients with breast carcinoma were analyzed to detect the COX-2, MVD and VEGF expression with immunohistochemistry. [Results] Expression of COX-2 was detected in 78.1% of breast carcinoma samples（57/71）, among which the expression above midrange was 47.9% （35/73）, and its expression level was associated significantly with axillary lymph node metastasis and stage of the tumor（ P 〈0. 01）. There was no significant correlation between COX-2 expression and the size of tumor, HER-2/neu expression and patients age （ P 〉0.05）. In addition, MVD and VEGF score was significantly different between COX-2 high-expression cases and COX-2 low-expression cases （ P〈0. 01）. [Conclusion] The data suggest that expression of COX-2 may promote the angiogenesis of tumor and influence the development and progression of breast carcinoma.

关 键 词：乳腺肿瘤/病理学 前列腺素内过氧化物合酶/分析 新生血管化 病理性 

分 类 号：R737.9[医药卫生—肿瘤]