高功能孤独障碍患儿感兴趣脑区组织密度的对照研究  

Case-control study on tissue density of brain region of interest in children with high functioning autism

作　　者：洪珊珊[1] 柯晓燕[1] 邹冰[2] 汤天宇[1] 李惠国[2] 周振宇[1] 杭跃跃[2] 阮宗才[1] 陆祖宏[1] 

机构地区：[1]东南大学学习科学研究中心.儿童发展与学习科学教育部重点实验室,江苏南京210096 [2]南京医科大学附属脑科医院儿童心理卫生研究中心

出　　处：《中国妇幼保健》2008年第20期2817-2819,共3页Maternal and Child Health Care of China

基　　金：国家自然科学基金(30570655);南京市医学重点科技发展项目(ZKX06025);南京市科技发展计划资助项目(200701109)

摘　　要：目的:探讨高功能孤独障碍患儿与正常儿童在结构磁共振成像上感兴趣脑区组织密度的差异。方法:在SPM平台上使用Anatomy工具箱测量了18名年龄6～14岁的高功能孤独障碍患儿和16名年龄、性别、智商、身高、体重与之相匹配的正常对照儿童结构磁共振成像上感兴趣脑区的组织密度。结果:高功能孤独障碍患儿左侧初级视觉皮层V1区的组织密度显著大于正常对照组(P<0.005);双侧海马内嗅皮质、右侧杏仁基底外侧核的组织密度显著小于正常对照组(P<0.005)。结论:学龄高功能孤独障碍患儿枕叶视觉皮层以及边缘系统的脑组织密度存在多处异常。Objective： To investigate tissue concentration difference in the regions of interest between children with high functioning autism and normal control in structure magnetic resonance imaging. Methods. Anatomy toolbox which based on SPM was used to measure 18 year 6 - 14 high functioning autism and 16 matched control tissue concentration. Results. Tissue concentration in high functioning autism was significantly larger in the left primary visual cortex V1 area than that in control （P 〈 0. 005） ; however significantly smaller in the bilateral Entorhinal cortex and right amygdala lateralbasal group than those in control （ P 〈 0. 005） . Conclusion. School age children with high functioning autism have demonstrated some disorders of the brain tissue concentration in the occipital lobe visual cortex and limhic system, which maybe the neurophysical basis of somatosensory, emotion and social cognition disorder of high functioning autism.

关 键 词：孤独障碍 磁共振成像 脑结构 组织密度 儿童精神病学 

分 类 号：R749[医药卫生—神经病学与精神病学]