海洋共附生微生物天然产物生物合成基因研究进展  

Advances on biosynthetic gene clusters of natural product from marine symbiotic microbe——A review

作　　者：许静[1] 徐俊[1] 

机构地区：[1]国家海洋局第三海洋研究所海洋生物遗传资源重点实验室,厦门361005

出　　处：《微生物学报》2008年第7期975-979,共5页Acta Microbiologica Sinica

基　　金：福建省青年科技人才创新项目(2005J063);国家自然科学基金(40606031);国家"973项目"(2006CB708200)~~

摘　　要：对海洋无脊椎动物天然产物的研究表明,很多种活性物质的真正生产者是与其共生或附生的未培养微生物。克隆这些未培养微生物中特定活性物质的生物合成基因,不仅为活性物质的来源提供遗传学证据,也使通过异源表达相关生物合成基因来大量获取目标化合物成为可能。本文综述了来源于海绵、海鞘、苔藓虫、深海管状蠕虫和深海沉积物中共附生微生物天然产物生物合成基因簇的研究进展。Previous research has suggested that the true producers of numerous natural products isolated from marine invertebrates were the microbial epibiont and symbiont which are deemed as not-yet-cultivated microbe. Cloning of the biosynthetic genes responsible for a specific nature product not only provides direct genetic evidence of the origin of the compounds but also establishes the feasibility of mass production of the compounds by heterologous expression. This paper reviews the progresses on the biosynthetic gene clusters of nature products from the symbiotic bacteria including marine sponge, ascidian, bryozoan, deep-sea tube worm and deep-sea sediments.

关 键 词：海洋共附生微生物 天然产物 生物合成基因簇 宏基因组文库 

分 类 号：Q93[生物学—微生物学]