纳洛酮对心肺复苏犬脑组织及肺组织形态学的影响  

EFFECT OF NALOXONE ON MORPHOLOGIC CHANGE OF BRAIN AND LUNG INDUCDED BY CARDIOPULMONARY RESUSCITATION OF CANINES

作　　者：叶显智[1] 刘炳烦[1] 张弋[1] 江慧琳[1] 许松青[1] 

机构地区：[1]广州医学院第二附属医院,广东广州510260

出　　处：《现代医院》2008年第7期16-17,共2页Modern Hospitals

摘　　要：目的通过观察心跳骤停犬给予纳洛酮干预后脑组织及肺组织形态学变化情况,了解纳洛酮对心肺脑复苏的作用。方法18只健康杂种犬,随机分成三组,每组6只,予体外电击诱发室颤,对照组:心跳骤停后予标准心肺复苏术;实验组:心跳骤停后予标准心肺复苏术+纳洛酮;空白组:不诱发室颤。于复苏后6小时取脑海马组织及肺组织行形态学检查。结果实验组脑组织及肺组织的病理损害低于对照组。结论使用纳洛酮后心肺复苏犬脑组织和肺组织的病理损害有所减轻,纳洛酮可减轻心肺复苏后脑组织和肺组织的再灌注损伤。Objective In order to study the effect of Naloxone on cardliopulmonary cerebral resuscitation, we examine the morphologic change of cerebral tissue and lung tissue in only restore of spontaneous circulation （ROSC） and with Naloxone after cardiac arrest. Methods 18 canine were randomly divided into CPR group, Naloxone group and blank group, n =6. Ventricular fibrillation （VF） was induced in CPR group and Naloxone group by the external electricity. The hippocampus and lung tissue were taken out after the 6-hour procedure and observed the morpholog- ic change. Results Compared with the CPR group, the pathological damage was mild. Conclusion Treatment with Naloxone can decreased the pathological damages in cerebral and lung tissue of postresuscitated canine and may be improved the reperfusion injury of postresuscitation.

关 键 词：心肺复苏 纳洛酮 再灌注损伤 犬 

分 类 号：R135.2[医药卫生—劳动卫生] R605.974[医药卫生—公共卫生与预防医学]