急、慢性咬合干扰致雌性大鼠咀嚼肌痛觉敏感的研究  

Hyperalgesia of Masticatory Muscles Induced by Acute and Chronic Occlusal Interference in Female Rats.

作　　者：陈霜 王美青 刘晓东 吴昊[2] 孙磊 刘蕾 

机构地区：[1]第四军医大学口腔医院解剖生理教研室,陕西西安710032 [2]第四军医大学统计教研室

出　　处：《口腔医学研究》2008年第3期248-251,共4页Journal of Oral Science Research

基　　金：国家自然科学基金国际合作资助项目(编号:30540130469)

摘　　要：目的:探讨咬合干扰对咀嚼肌机械压痛敏感性的影响。方法:对大鼠施以急、慢性咬合干扰,设空白对照和去咬合干扰对照,测量实验前及实验后15d颞肌和咬肌对von Frey尼龙毛刺激反应阈值,以累加logit模型作组间比较。结果:急、慢性咬合干扰均可增高咀嚼肌痛敏分值(P<0.05),急性咬合干扰组更明显,敏感程度由大到小为:干扰侧颞肌、干扰侧咬肌、干扰对侧颞肌(P<0.05),对干扰对侧咬肌的影响不明显。结论:咬合干扰可致咀嚼肌痛觉敏感。Objective： To investigate the effect of occlusal interference on mechanical hyperalgesia of masticatory muscles in the Sprague-Dawley rats. Methods： Acute and chronic occlusal interference were established on the left molars, and blank group and occlusal interference remove groups were served as control. The mechanical stimulation was applied with von-Frey monofilaments from 0 to 15 days. Cumulative Logits models were used to analyze the pain score. Results： The pain score of acute interference group was significantly higher than that of chronic occlusal interference group, and both of them were higher than that of blank control group （ P〈0.05 ）. The pain score of muscles was followed： ipsilateral temporalis 〉 ipsilateral masseter muscle 〉 contralateral temporalis （ P〈0.05 ）. It was not obvious in contralateral masseter muscle. Conclusion, Occlusal interference could lead to masticatory muscles hyperalgesia.

关 键 词：咬合干扰 咀嚼肌 疼痛 动物行为学 

分 类 号：R782.6[医药卫生—口腔医学]