家族性肥厚型心肌病易感基因与HLA-DQ位点相关性分析  

Study on the linkage between the hypertrophic cardiomyopathy of family lineage and HLA DQ

作　　者：张修武[1,2] 张之炯[1,2] 郭迅[1,2] 郭兆贵 

机构地区：[1]湖南医科大学分子药理研究室 [2]湖南医科大学附属湘雅医院心内科

出　　处：《中华微生物学和免疫学杂志》1997年第5期352-355,共4页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金

摘　　要：本文报道应用ＰＣＲ／ＳＳＯ方法分析了４个无肌凝蛋白重链基因突变的肥厚型心肌病多发家系成员ＨＬＡ－ＤＱ基因多态性，进行患病同胞共享ＨＬＡＤＱＡ１／ＤＱＢ１单倍型分析和Ｌｏｄｓ分析。结果表明，本病的易感基因与ＨＬＡ－ＤＱ基因存在连锁关系。提示在ＨＬＡ－ＤＱ座位附近可能存在与家族性肥厚型心肌病易感性有关的致病基因。Using PCR/SSO technique,we analyzed DQA1 and DQB1 polymorphism of the members in 4 families with hypertrophic cardiomyopathy which were determined no mutation in β myosin heavy chain gene by PCR SSCP method.The results of identical HLA haplotype and Lods analysis showed that there was a linkage between the susceptible gene of the disease and HLA DQ haplotype.This suggests that a susceptible gene of hypertrophic cardiomyopathy might be nearby HLA DQ locus.

关 键 词：肥厚型心肌病 连锁分析 HLA-DQ 基因多态性 

分 类 号：R542.202[医药卫生—心血管疾病] R596.102[医药卫生—内科学]