郭迅

作品数:16被引量:8H指数:2
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供职机构:中南大学湘雅医学院更多>>
发文主题:WESTERN_BLOTTINGCALMODULINP42HLA-DQ肥厚型心肌病更多>>
发文领域:医药卫生生物学更多>>
发文期刊:《Acta Pharmacologica Sinica》《中华微生物学和免疫学杂志》《中国药理学与毒理学杂志》更多>>
所获基金:国家自然科学基金更多>>
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VEGF protects bovine aortic endothelial cells from TNF-α-and H_2O_2-induced apoptosis via co-modulatory effects on p38- and p42 p44-CCDPK signaling
《Acta Pharmacologica Sinica》2002年第1期45-49,共5页刘文兰 郭迅 陈清泉 郭兆贵 
To investigate the effect of VEGF on TNF-α-or H2O2 induced apoptosis in cultured bovine aortic endothelial cells (BAEC) and the underlied signal trans-duction mechanisms related to Ca2+ -calmodulin dependent protein ...
关键词:apoptosis DNA fragmentation Ca2+-calmodulin dependent protein kinase tumor necrosis factor hydrogen peroxide endothelial growth factors Western blotting vascular endothelium cultured cells 
VEGF protects bovine aortic endothelial cells from TNF-α-and H<sub>2</sub>O<sub>2</sub>-induced apoptosis via co-modulatory effects on p38- and p42 p44-CCDPK signaling
《Acta Pharmacologica Sinica》2002年第1期47-51,共页刘文兰 郭迅 陈清泉 郭兆贵 
To investigate the effect of VEGF on TNF-α-or H2O2 induced apoptosis in cultured bovine aortic endothelial cells (BAEC) and the underlied signal trans-duction mechanisms related to Ca2+ -calmodulin dependent protein ...
关键词:apoptosis DNA fragmentation Ca2+-calmodulin dependent protein kinase tumor necrosis factor hydrogen peroxide endothelial growth factors Western blotting vascular endothelium cultured cells 
Opposing effect of p38 CCDPK and p44/42 CCDPK signaling on TNF-α-induced apoptosis in bovine aortic endothelial cells
《Acta Pharmacologica Sinica》2001年第5期25-30,共6页刘文兰 郭迅 陈清泉 郭兆贵 
AIM: To investigate the pro-apoptotic role of tumor necrosis factor α (TNF-α) in cultured bovine aortic en-dothelial cells (BAEC) and its underlied apoptotic signaling pathways. METHODS: BAEC were cultured and passa...
关键词:apoptosis DNA fragmentation Ca2+- calmodulin dependent protein kinase tumor necrosis fac- tor Western blotting vascular endothelium cultured cells 
Effects of p38 and p42/p44 CCDPK signaling on H_2O_2-mduced apoptosis in bovine aortic endothelial cells
《Acta Pharmacologica Sinica》2000年第11期33-38,共6页刘文兰 郭迅 郭兆贵 
AIM: To investigate the effects of p38 and p42/p44 Ca2+ -calmodulin dependent protein kinases (CCDPK) signaling on hydroperoxide (H2O2) -induced apoptosis in cultured bovine aortic endothelial cells (BAEC). METHODS: M...
关键词:APOPTOSIS DNA fragmentation Ca2+-calmodulin dependent protein kinase hydrogen peroxide Western blotting vascular endothelium cultured cells 
High glucose inhibits expression of inducible and constitutive nitric oxide synthase in bovine aortic endothelial cells
《Acta Pharmacologica Sinica》2000年第4期325-328,共4页郭迅 谌立伟 刘文兰 郭兆贵 
AIM: To investigate the effects of high glucose on the expression of nitric-oxide synthase (NOS) in cultured bovine aortic endothelial cells (BAEC). METHODS: BAEC were cultured and passaged in normal glucose (NG) 5.5 ...
关键词:nitric-oxide synthase glucose lipopo- lysaccharides Western blotting vascular endothelium cultured cells 
High glucose impairs endothelium-dependent relaxation in rabbit aorta
《Acta Pharmacologica Sinica》2000年第2期75-79,共5页郭迅 刘文兰 谌立伟 郭兆贵 
AIM: To study the effects of high glucose on endotheli-um-dependent relaxation (EDR) and the action of L-argi-nine, superoxide dismutase (SOD), or glucose re-normalization in aorta. METHODS: Measurement of EDR of the ...
关键词:relaxation GLUCOSE ACETYLCHOLINE PHENYLEPHRINE sodium nitroprusside ARGININE superox-ide dismutase vascular endothelium thoracic aorta 
High glucose enhances H_2O_2-induced apoptosis in bovine aortic endothelial cells
《Acta Pharmacologica Sinica》2000年第1期43-47,共5页郭迅 刘文兰 谌立伟 郭兆贵 
AIM: To investigate the effect of high glucose on hy-droperoxide ( H2O2 )-induced apoptosis in cultured bovine aortic endothelial cells (BAEC). METHODS: BAEC were cultured and passaged in normal glucose (5.5 mmol·L-1...
关键词:APOPTOSIS DNA fragmentation Ca2+ -calmudulin dependent protein kinase hydrogen peroxide GLUCOSE Western blotting vascular endothe-lium cultured cells 
高糖增强兔血管平滑肌细胞对内皮素-1的增殖反应性(英文)
《中国药理学报》1999年第6期521-524,共4页郭迅 刘文兰 易富贤 郭兆贵 
观察高糖对内皮素-1(ET-1)促兔主动脉血管平滑肌细胞(VSMC)增殖的影响.方法: VSMC分别培养于含正常葡萄糖、高糖或高渗(5.5,25,葡萄糖 5.5+甘露醇 19.5 mmol·L-1)的培养基中[3H]胸腺...
关键词:葡萄糖 内皮素-1 血管平滑肌 增殖 增殖反应性 
牛心内膜腺苷三磷酸双磷酸酶对血小板聚集的抑制作用(英文)
《中国药理学报》1999年第9期851-854,共4页易富贤 黄韶玲 郭迅 孙平 郭兆贵 
目的:研究牛心内膜内皮细胞(EEC)腺苷三磷酸双磷酸酶的抗血小板聚集效应。方法:培养牛EEC。以高效液相色谱法测定ADP,用比浊法测血小板聚集。结果:ADP 500μmol·L^(-1)与EEC温孵后,引起ADP浓度进行性地降低。与此相适应的是,未代谢的AD...
关键词:腺苷三磷酸 双磷酸酶 心内膜 血小板聚集 
溶血性磷脂酰胆碱和血管内皮对5—羟色胺收缩离体兔动脉 …
《中国药理学与毒理学杂志》1999年第2期85-88,共4页谌立伟 郭迅 
在离体兔胸心动脉环模型上观察溶血性磷脂酰胆碱(LPC)促血管收缩作用的机理以及血管内皮对LPC促血管收缩作用的影响。10μmol·L^-1LPC预温育30min可显著增强兔胸主动脉环对5-羟色胺(5-HT)的收缩反应...
关键词:溶血磷脂酰胆碱 血管收缩 血管内皮 5-羟色胺 
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