OCT检测在正常眼压性青光眼和生理性大视杯诊断中的应用  

Comparative study of the value of OCT for normal tension glaucoma and physiologic large cups

作　　者：董映[1] 胡勇平[1] 王雅娜[1] 陈滨[1] 

机构地区：[1]杭州市第一人民医院眼科,杭州310006

出　　处：《中国中医眼科杂志》2008年第3期175-177,共3页China Journal of Chinese Ophthalmology

摘　　要：目的探讨光学相干断层成像术(OCT)检测视盘参数及神经纤维层在正常眼压性青光眼早期诊断中的价值。方法用OCT对15例(30眼)正常人、20例(30眼)正常眼压性青光眼和15例(30眼)生理性大视杯进行视盘和神经纤维层扫描及参数分析。从参数中选择视盘直径、视盘面积、视杯直径、视杯面积、盘沿面积、杯盘面积比、杯盘水平径比、杯盘垂直径比、垂直盘沿容积及平均神经纤维层厚度进行统计学分析。结果OCT检测正常组、生理性大视杯及正常眼压性青光眼三组间各视盘及神经纤维层参数差异均有统计学意义(P<0.05);两组参数之间的相互比较:正常眼与生理性大视杯在平均视网膜神经纤维层厚度参数之间差异无统计学意义(P>0.05);正常眼与正常眼压性青光眼在视盘直径与视盘面积两组参数之间差异无统计学意义(P>0.05);生理性大视杯与正常眼压性青光眼在视杯直径参数之间差异无统计学意义(P>0.05),余两组之间参数差异均有统计学意义(P<0.05)。结论OCT能做出视盘及神经纤维层的定量测量和分析,重复性好,可作为早期诊断正常眼压性青光眼的手段。OBJECTIVE To study the value of OCT for normal tension glaucoma and physiologic large cups.METHODS This trial involved 15 （30 eyes） normal control subjects,20 （30 eyes） patients with normal tension glaucoma and 15 （30 eyes） persons with physiologic large cups. Their parameters of optic disk were measured using opti- cal coherent tomography （OCT）. RESULTS There were no significant difference in average RNFL between normal control subjects and persons with physiologic large cups（ F = 1.69, P 〉 0.05） ;the disk diameter and disk area between norreal control subjects and patients with normal tension glaucoma had no significant difference（ F = 0.0195, P 〉 0.05; F = 0. 0563, P 〉 0.05） ; the cup diameter between persons with physiologic large cups and patients with normal tension glaucoma also had no significant difference （ F = 2.45, P 〉 0.05） .There were significant differences in other parameters（ P 〈 0.05） among the three groups. CONCLUSIONS OCT may serve as a useful diagnostic modality in distinguishing physiologic large cups from normal tension glaucoma, even in the early stage of glaucoma.

关 键 词：正常眼压性青光眼 生理性大视杯 光学相干断层成像术 

分 类 号：R775.1[医药卫生—眼科]