炎症因素与脑梗死患者颈动脉粥样硬化的关系  

Association between the inflammatory factors and carotid atherosclerosis in patients with cerebral infarction

作　　者：潘元美[1] 李焰生[1] 林岩[1] 

机构地区：[1]上海交通大学医学院附属仁济医院神经内科,200127

出　　处：《临床神经病学杂志》2008年第3期174-176,共3页Journal of Clinical Neurology

基　　金：上海市科委重大攻关项目(03DZ13704)

摘　　要：目的探讨炎症因素与脑梗死患者颈动脉粥样硬化的关系。方法对244例急性缺血性脑卒中患者的颈动脉内膜中层厚度(IMT)及斑块情况和血液炎症性生化指标进行相关性分析。结果炎症因素(单核细胞比例,纤维蛋白原,C-反应蛋白水平,血沉)和颈动脉粥样硬化相关,其中单核细胞比例(ORIMT=1.231,P<0.01;OR斑块=1.175,P<0.05)及血沉增高(ORIMT=1.024,OR斑块=1.029,均P<0.01)具有独立预测性,单核细胞比例的独立预测性最高。炎症因素和斑块稳定性之间无相关性。结论单核细胞比例及血沉可独立预测颈动脉粥样硬化的发生。Objective To investigate the association between the inflammatory factors and carotid atherosclerosis in patients with cerebral infarction. Methods The carotid intima-media thickness（IMT） , plaque and inflammatory indexes were correlative analysed in 244 patients with acute cerebral infarction. Results Inflammatory factors （ monocyte proportion, levels of fibrinogen and CRP, erythrosedimentation ） were associated with carotid atherosclerosis. Monocyte proportion （ ORIMT = 1.231, P 〈 0.01 ; ORplaque = 1.175, P 〈 0. 05 ） and erythrosedimentation （ORIMT = 1. 024, ORplaque = 1. 029, all P 〈 0. 01 ） were independent predictors of carotid atherosclerosis. The independent predictability of monocyte proportion was the highest. There were no associations of inflammatory foctors with stability of carotid plaque. Conclusion Monocyte proportion and erythrosedimentation are independent predictors of carotid atherosclerosis.

关 键 词：颈动脉粥样硬化 颈动脉斑块 内膜中层厚度 炎症因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]