鱼油补充对哮喘儿童肺通气功能影响  

Effect of fish oil supplementation on pulmonary ventilation function of children with asthma

作　　者：赵飞[1] 乔艳红[1] 刘丰[1] 王一彪[1] 

机构地区：[1]山东大学第二医院儿科,济南250033

出　　处：《中国公共卫生》2008年第7期780-781,共2页Chinese Journal of Public Health

基　　金：山东省医药科技发展计划课题(2007BZ16)

摘　　要：目的探讨补充鱼油对哮喘儿童诱导痰中性粒细胞占百细胞百分数(Neu%)、嗜酸粒细胞占白细胞白分数(E S%)、白细胞介素8(IL-8)、嗜酸粒细胞趋化因子(Eotaxin)及肺通气功能的影响。方法63例哮喘儿童随机分为常规治疗组和治疗组,常规治疗组采用常规治疗,治疗组除常规治疗外,每日补充鱼油,治疗8周,并分别于治疗前后行肺通气功能及诱导痰中性粒细胞,嗜酸粒细胞占白细胞百分数I、L-8、eotaxin等检查。结果哮喘儿童诱导痰Neu%、IL-8增高,并分别与肺通气功能指标第1秒最大呼气量(FEV1.0%)及呼气峰流速(PEF%)呈负相关(P<0.01),EOS%、eotaxin无显著增高(P>0.05);与常规治疗组治疗后比较,治疗组在治疗后Neu%、IL-8均显著降低,FEV1.0%、PEF%显著升高(P<0.05)。结论饮食中补充鱼油具有减轻哮喘儿童气道炎症,提高肺通气功能的作用。Objective To study the effects of fish oil supplementation on the percentage of neutrophils（Neu % ）, the percentage of eosinophils（EOS% ）, interleukin- 8（ IL- 8）, eotaxin in induced sputum and on pulmonary ventilation function of children with asthma. Methods 63 children with asthma were randomly divided into two groups： conventional group and treatment group. The conventional group was treated with conventional methods. The treatment group was given additional fish oil supplementation besides conventional treatment. IL - 8, eotaxin, Neu%, EOS% in induced sputum and FEV1.0 %, PEF% were measured before and after the treatment. Results The Neu%, IL - 8 in sputum increased and negatively corre- lated with FEV1.0 %, PEF% （P〈 0.01） among the children with asthma. Compared with conventional group, the Neu%, IL - 8 decreased significantly and FEV1.0 %, PEF % increased（P 〈 0.05） among treatment group after the treatment. Conclusion The fish oil supplementation improves ventilation by alleviating airway inflammation in children with mild - moderate asthma.

关 键 词：哮喘 鱼油 嗜酸粒细胞趋化因子 白细胞介素-8 

分 类 号：R563[医药卫生—呼吸系统] R473.72[医药卫生—内科学]