氦氖激光对心肌梗死大鼠血清自由基影响  

Effect of He-Ne laser on serum free radicals in rats with myocardial infarction

作　　者：杨颖[1] 张杰梅[2] 庞东卫[3] 徐洋[4] 

机构地区：[1]包头医学院物理教研室,内蒙古包头014010 [2]包头医学院第一附属医院心内科 [3]包头医学院生理教研室 [4]包头医学院第一附属医院物理诊断科,内蒙古包头014010

出　　处：《中国公共卫生》2008年第7期824-825,共2页Chinese Journal of Public Health

基　　金：内蒙古自然科学基金项目(200208020619)

摘　　要：目的探讨氦氖激光对心肌梗死大鼠血清中超氧化物歧化酶(SOD)、丙二醛(MDA)和一氧化氮(NO)的影响。方法以特定的氦氖激光强度、经不同的照射时间照射心肌梗死大鼠心前区,观察血清自由基水平的改变。结果氦氖激光照射心肌梗死大鼠心前区10和20min时血清中SOD升高(48.86,50.22 U/ml),与对照组比较(44.28U/ml),差异有统计学意义(P<0.05);MDA降低(3.94,3.99 nmol/L),与对照组比较(4.78nmol/L),差异有统计学意义(P<0.05);照射20min时血清中NO升高(388.86μmol/L),与对照组比较(286.46μmol/L),差异有统计学意义(P<0.05)。结论氦氖激光照射心前区对于冠心病、心肌缺血的治疗有一定意义。Objective To probe into the effect of He- Ne laser on superoxide dismutase （SOD）, malon- dialdehyde （MDA） and nitric oxide（NO） in the serum of the rats with myocardial infarction. Methods The myocardial infarcted rats were irradiated on their precordial regions by HE- Ne laser with certain intensity for different time to observe changes of serum free radical levels. Results Compared with the control group（44.28U/ml）, the content of SOD in myocardial infarcted rats irridiated by He- Ne laser for 10 and 20 min increased significantly（48.86, 50.22 U/ml, P 〈 0.05 ）. Compared with the control group（4.78 nmol/L）, the content of serum MDA decreased significantly （3.94, 3.99 nmol/L, P 〈 0.05 ）. By 20min irradiating, compared with the control group（286.46μmol/L）, the content of NO in rats＇ serum increased significantly （388.86μmol/L, P 〈 0.05）. Conclusion He- Ne laser irradiation on the precordial region has certain significance in treating coronary heart disease and myocardial ischemia.

关 键 词：氦氖激光 心肌梗死 心前区 自由基 

分 类 号：R151.2[医药卫生—营养与食品卫生学]