孤独症儿童及期I级亲属血浆五羟色胺水平的对照研究  

A control study on plasma serotonin in autistic probands and their first degree relatives

作　　者：卢建平[1] 闫小华[1] 邓小敏[1] 舒明跃[1] 杨志伟[1] 

机构地区：[1]深圳市康宁医院,深圳518020

出　　处：《中国行为医学科学》2008年第7期617-618,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的通过测定儿童孤独症核心家系五羟色胺（5-HT）水平，探讨孤独症先证者及其I级亲属的5-HT水平的家族聚集性特征。方法采用高效液相色谱仪测定儿童孤独症组（38例）及其亲生父母组（61例）的5-HT水平，并与年龄和性别相匹配的正常儿童对照组（35例）及正常成人对照组（60例）的5-HT水平相比较。结果①儿童孤独症组的血浆5-HT水平为（212．51±127．98）μmol／L，显著高于正常儿童对照组（t=3．842，P=0．000）；②孤独症父母组的血浆5-HT水平为（88．15±48．15）μmol／L，显著高于正常成人对照组（t=3．409，P=0．001）。③儿童孤独症的病情严重程度与血浆5-HT水平两者之间无显著相关（r=0．142，P=0．041）。④孤独症儿童组的血浆5-HT水平与孤独症儿童的父亲和母亲的血浆5-HT水平两者之间均存在显著相关（r=-0．498，P：0．000；r=-0．602，P=0．000）。结论儿童孤独症血浆5-HT增高并与遗传因素相关，可作为中间表型为孤独症遗传易感因子的研究提供线索。Objective To investigate the familial aggregation of 5-HT level in parents of autistic probands. Methods In a sample of 38 autistic subjects and 61 of their parents,compared to age and sex matched controls. 5-HT were measured by HPLC. Results The level of 5-HT in autistic children was significant higher than the controls subjects（ t =3. 842, P = 0. 000）. The significant difference of 5-HT level between autism children parents and normal children parents was found（ t = -3. 409, P=O. 001 ）. The severity degree of autism was not significant related to the 5-HT level（ r=0. 142, P=O. 041 ）. The 5-HT level of autistic children was significant related to the 5-HT level of their parents （ r = - 0. 498, P = 0. 000 ; r = - 0. 602, P = 0. 000 ）. Conclusion Elevated 5-HT level may be associated with genetic liability to autism and help the search of genetic susceptibility factors in autism.

关 键 词：5-HT 儿童孤独症 家族聚集性 遗传 

分 类 号：R749.94[医药卫生—神经病学与精神病学]