低水平全身照射抑制B_(16)黑色素瘤血道肺转移的机理研究  

Mechanism of low level ionizing radiation in inhibiting B 16 melanoma blood borne pulmonary metastasis.

作　　者：金敖兴[1] 汪思应[1] 魏道严[1] 黄帼[1] 

机构地区：[1]安徽医科大学核医学教研室

出　　处：《中华放射医学与防护杂志》1997年第4期236-238,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金

摘　　要：探讨低水平照射抑制Ｂ１６黑色素瘤血道肺转移的机理。方法用１２５Ｉ标记Ｂ１６黑色素瘤细胞，观察了低剂量照射对小鼠体内Ｂ１６细胞的分布及清除率的影响。结果７．５ｃＧｙＸ射线单次全身照射后，小鼠肺各时相对肿瘤细胞清除率较对照组有明显提高（Ｐ＜０．０１），存留于血、肺、肝、脾中的标记肿瘤细胞量减少；与此同时，照后２４小时检测小鼠免疫功能发现，小鼠脾细胞ＮＫ活性、淋巴细胞转化率（ＬＴＲ）及巨噬细胞（Ｍ）吞噬功能明显增强。结论７．５ｃＧｙＸ射线照射可通过增强ＮＫ细胞。Objective To study the mechanism of low level ionizing radiation in inhibiting B 16 melanoma blood borne pulmonary metastasis. Method 125 I labelled B 16 melanoma cells were used to investigate the effect of low dose X irradiation on the distribution and clearance of tumor cells in mice. Results After whole body 7.5 cGy X irradiation,the clearance of tumor cells was siginificantly increased from lungs of mice.The residual numbers of tumor cells were markedly lower than those of control in blood,spleen,liver and lungs ( P <0 05—0 01).The cytotoxicity of murine splenic NK cells,LTR and the phagocytosis of macrophages augmented significantly after the mice were irradiated with low dose X rays. Conclusion These results suggest that the enhancement of NK cytotoxicity and macrophage phagocytotic function might be one of the important reasons why low dose radiation can accelerate the clearance of tumor cells from the lungs.

关 键 词：电离辐射 抑制 B16 黑色素瘤 肺转移 免疫功能 

分 类 号：R739.505[医药卫生—肿瘤]