脑胶质瘤缺氧诱导因子-1α、血管内皮生长因子的表达及意义  

Expression and clinical significance of hypoxia inducible factor-1α and vascular endothelial growth factor in human gliomas

作　　者：檀艳丽[1] 方川[2] 孙贺英[1] 高伟敏[1] 王佳良[2] 丁亚楠[2] 刘海鹏[2] 

机构地区：[1]河北大学医学部,河北保定071000 [2]河北大学附属医院

出　　处：《山东医药》2008年第21期4-6,共3页Shandong Medical Journal

基　　金：河北省科技厅科技攻关计划资助项目(06276102D-20);河北大学附属医院青年基金资助项目(2005Q001)

摘　　要：目的探讨脑胶质瘤缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)的表达变化及其与微血管密度(MVD)的关系,以及HIF-1α、VEGF与人脑胶质瘤病理分级、血管生成的关系。方法采用免疫组化SP法检测54例脑胶质瘤组织中HIF-1、VEGF的表达情况及MVD。结果54例脑胶质瘤组织HIF-1α的表达阳性率为61.1%(33/54),VEGF为70.4%(38/54),其表达强度与脑胶质瘤的病理分级呈正相关(P<0.05)。HIF-1α的表达与VEGF的表达及MVD均呈正相关(P均<0.05)。结论HIF-1α、VEGF与脑胶质瘤组织中血管生成与病理分级密切相关,可作为有意义的预后判断指标。Objective To evaluate the relationship among hypoxia inducible factor-1α（HIF-1α） , vascular endothelial growth factor （VEGF） and microvessel density（MVD） and to investigate their association with pathological grades and anglogenesis of human gliomas. Method The expression of HIF-1α,VEGF as well as the proteins associated with MVD in the gliomas were studied by SP immunohistochemical staining. Results The positive rate of HIF-1α expression in human gliomas of 54 cases was 61.1% （33/54） and that of VEGF was 70. 4% （38/54） ,which were related with the histological grade of tumor（P 〈 0. 05）. The expression of HIF-1 α was positively correlated with VEGF and MVD （P 〈 0. 05 ）. Conclusions HIF-1α and VEGF correlate positively to histological grade and angiogenesis. The expressions of them can be used to assess the prognosis in glioma patients.

关 键 词：脑肿瘤 胶质瘤 缺氧诱导因子-1Α 血管内皮生长因子 微血管密度 

分 类 号：R739.41[医药卫生—肿瘤]