食管癌血清标记物研究进展  

Advances in serum biomarkers of esophageal carcinoma

作　　者：李波波(综述)[1] 李道堂(审校)[1] 

机构地区：[1]山东省肿瘤防治研究院胸外科,济南250117

出　　处：《国际肿瘤学杂志》2008年第6期444-446,共3页Journal of International Oncology

摘　　要：近年来，蛋白质组学技术的发展不仅使癌胚抗原（CEA）、鳞状上皮细胞癌抗原（SCC-Ag）等临床常用的肿瘤标记物的阳性率明显提高，而且筛选出许多新的与食管癌相关的血清学肿瘤标记物，如血管内皮生长因子、血管生成素、Dickkopf 21蛋白、肿瘤M2型丙酮酸激酶等，对这些新的标记物的临床研究，有可能改变食管癌诊断和治疗的现状。Recently, with the development of techniques such as proteomics, the positive rate of common tumor markers, such as carcinoembryonic antigen （CEA） and squamous cell carcinomatous antigen （ SccAg） has increased obviously. And some new tumor markers related to esophageal carcinoma （EC） have been detected, such as vascular endothelial growth factor, angiopoietin, Dickkopf 21, tumor M2-PK and etc. Clinical trials are undergoing to estimate the value of these markers ,which may change the current status of EC diagnosis and therapy.

关 键 词：食管肿瘤 肿瘤标记 生物学 血清学 

分 类 号：R730.45[医药卫生—肿瘤] R735.1[医药卫生—临床医学]