急性脑梗死血清C反应蛋白水平的临床意义  

Clinical Significance of C-reaction Protein in Patients with Acute Cerebral Infarction

作　　者：郭丽娟[1] 邓晓波 王德生[1] 王鸿慧[1] 李国忠[1] 

机构地区：[1]哈尔滨医科大学附属第一临床医学院神经内科,黑龙江哈尔滨150001 [2]黑龙江省人民医院,黑龙江哈尔滨150001

出　　处：《中国神经免疫学和神经病学杂志》2008年第4期279-281,共3页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的探讨急性脑梗死(ACI)患者血清C反应蛋白(CRP)水平的意义及其机制。方法测定129例ACI患者、46名健康对照者血清CRP水平,观察比较ACI患者在不同病情、不同梗死面积时血清CRP水平的变化,对发病后48h病情发展变化进行评定,根据评分结果分为进展型与完全型脑梗死两组进行观察比较。结果ACI患者血清CRP水平[(0.81±0.48)mg/dL]明显高于健康对照组[(0.27±0.16)mg/dL](P<0.01),且CRP水平随神经功能缺损程度评分增高亦明显升高;进展性脑梗死患者血清CRP水平明显高于非进展性患者(P<0.01)。结论CRP一定程度上是预测ACI患者病情严重程度及进展的相关生化指标之一。Objective To investigate the change and its mechanism of C-reactive protein（CRP） content in patients with acute cerebral infarction（ACI）. Methods The content of serum CRP in 129 patients with ACI and 46 normal control were measured. The changes of CRP were compared with patients of different pathogenetic condition and infarction areas. The disease progress were evaluated in 48 h after cerebral ischemic stroke. The patients were divided into progressive stroke and complete stroke. Results The level of CRP in patients with ACI increased significantly comparing with control group （P〈0.01）. The level of serum CRP was increasing with scores of neurofunction detected and extensions of the infarction area The serum levels of CRP in the progressive group were significantly higher than that in the complete group（P〈0.01）.Conclusions The CRP could be one of the indexes to predict the prognosis of ACI.

关 键 词：C反应蛋白 急性脑梗死 免疫比浊法 

分 类 号：R743.3[医药卫生—神经病学与精神病学]