单核细胞趋化蛋白-1和血管内皮细胞生长因子在人皮肤血管瘤中的表达及其相关性  

The Correlation between Monocyte Chemoattractant Protein-1 and Vascular Endothelial Cell Growth Factor Expression in Skin Hemangioma Tissue

作　　者：徐圣康[1] 赵猛[1] 刘家国[1] 张劲松[1] 王玉荣[2] 

机构地区：[1]郧阳医学院附属太和医院创伤骨科,湖北十堰442000 [2]华中科技大学同济医学院附属协和医院整形外科,湖北武汉430022

出　　处：《郧阳医学院学报》2008年第3期211-214,F0003,共5页Journal of Yunyang Medical College

摘　　要：目的:探讨单核细胞趋化蛋白-1(MCP-1)和血管内皮细胞生长因子(VEGF)在人皮肤血管瘤发生、发展及退化过程中的表达及其相关性。方法:采用免疫组化方法(SP法)和计算机图像分析技术,检测人皮肤血管瘤增生期、消退期及正常皮肤中的MCP-1、VEGF的平均阳性面积率和平均光密度。结果:增生期血管瘤与消退期血管瘤、正常皮肤组分别相比,MCP-1、VEGF阳性表达的平均光密度和平均阳性面积率有显著性差异(P<0.05);消退期血管瘤与正常皮肤组之间,MCP-1、VEGF阳性表达率无显著性差异(P>0.05);MCP-1、VEGF阳性面积表达率呈明显的正相关(r=0.746,P<0.05)。结论:MCP-1、VEGF在人皮肤血管瘤过度增生中起着重要的作用,且二者之间可能具有相互协同作用。Objective To explore the expression of monoeyte ehemoattraetant protein - 1 （MCP-1） and vascular endothelial cell growth factor（VEGF） in hemangioma and the relationship between MCP-1 and VEGF. Method ： MCP-1 and VEGF expression in 36 eases with hemangioma were detected with irnmunohistoehemistry. The average optical density and the positive area of MCP-1 and VEGF expression in specimens with different stage hemangioma were analyzed with image analysis. Results： Compared regression stage of hemangioma or normal skin tissues, MCP-1 and VEGF protein expression was significantly higher in proliferative hemangioma（ P 〈 0. 05 ）. There was no statistically significant difference in MCP-1 and VEGF expression between regression stage of hemangioma and normal skin tissues （ P 〉 0. 05 ）. There was a positive correlation between MCP-1 and VEGF in the proliferative hemangioma（ r =0. 746 ,P 〈 0. 05 ）. Conclusion： These results suggest that MCP-1 and VEGF play an important role in abnormal angiogenesis of capillary endothelial cells, during the development of hemangioma.

关 键 词：MCP-1 VEGF 血管瘤 血管生成 免疫组化 

分 类 号：R739.5[医药卫生—肿瘤]