中度海洛因依赖者肝肾损害及其危险因素分析  

Analysis of hepatorenal damage and risk factors in moderate heroin-dependent patients

作　　者：梁红卫[1] 孙莉[1] 沈黎阳[1] 邓艳萍[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100083

出　　处：《药物不良反应杂志》2008年第3期153-157,共5页Adverse Drug Reactions Journal

基　　金："国家重大基础研究973计划"资助项目(2003CB515400)

摘　　要：目的:分析中度海洛因依赖者肝、肾功能损害及其危险因素。方法:将最近1周每日平均吸食海洛因量<2.0g、戒断症状评分总分为65～140分的中度海洛因依赖者纳入研究,回顾性分析1455例肝功能和1407例肾功能指标及影响因素。结果:肝功能指标异常率分别为ALT45.43%、AST38.63%、TBil17.11%;肾功能指标异常率为BUN6.25%、Cr4.12%。多重Logistic回归分析显示:ALT异常的危险因素是性别、滥用时间和途径,OR分别为0.653、1.150和2.263;AST异常的危险因素是性别、滥用途径,OR分别为0.692、2.447。结论:中度海洛因依赖者的肝损害程度大于肾损害;滥用时间较长者ALT异常的风险较高,男性患者和静脉途径给药引起ALT和AST异常的风险高于女性患者和其他给药途径。Objective： To analyze the hepatorenal damage and risk factors in moderate heroin-dependent patients. Methods： The moderate heroin-dependent patients who abused heroin 〈 2.0 g/d in the last week and whose scores of the abstinence syndrome were 65 - 140 entered the study. The liver function indices in 1 455 cases, renal function indices in 1 407 cases, and risk factors were analysed retrospectively. Results： The percentages of abnormal ALT, AST, TBil, BUN, and Cr levels were 45.43%, 38.63%, 17. I 1% , 6.25% , and 4.12% , respectively. Multivariate Log/st/c regression analysis showed that risk factors for abnormal ALT were sex, duration and route of drug abuse （ OR was 0. 653, 1. 150, and 2. 263, respectively） ; and risk factors for abnormal AST were sex and route of drug abuse （OR was 0.692 and 2. 447, respectively）. Conclusion： The severity of liver damage is higher than that of renal damage in moderate heroin-dependent patients. The risk for abnormal ALT is higher in the patients with a longer term of abuse. The risk for abnormal ALT and AST in male patients and intravenous route administration is higher than in female and other route of administration .

关 键 词：中度海洛因依赖者 肝肾功能损害 危险因素 

分 类 号：R749.64[医药卫生—神经病学与精神病学]