中国北方人群系统性红斑狼疮患者KIR基因多态性的研究  

Study on the polymorphism of killer cell immunoglobulin like receptor (KIR) gene with systemic lupus erythematosus of North population in China

作　　者：陈阿梅[1] 刘庆平[1] 崔晓迎[2] 崔明玉[2] 闫文瑛 谢松梅 朱娜 王新党 

机构地区：[1]大连大学生物工程学院,辽宁大连116622 [2]内蒙古医学院组织学与胚胎学教研室,内蒙古呼和浩特010059 [3]山东脐带血造血干细胞库,山东济南250002

出　　处：《细胞与分子免疫学杂志》2008年第8期811-813,共3页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金资助项目(30371380,30571733);内蒙古自然科学基金资助项目(200607010920)

摘　　要：目的:检测和分析系统性红斑狼疮患者的杀伤细胞免疫球蛋白样受体(KIR)基因的多态性,探讨系统性红斑狼疮(SLE)从基因到临床表达的发病机制。方法:应用PCR-SSP技术检测北方62例确诊SLE患者和61例同一区域同一民族正常对照者的KIR基因位点多态性。结果:SLE患者KIR基因表型分布较常见的为KIR3DP1、2DL1、2DP1、3DL1、2DL3及1D,其次为2DS4、2DL5、3DS1、2DS2、2DS5和2DL2,较低者为2DS1、2DS3及3DP1V,SLE病例组KIR3DS1,2DL2、2DL5和2DL3基因型频率比对照组显著降低(P<0.01)。结论:中国北方人群的SLE的发生可能与多个KIR基因等位基因有相关性。AIM： To investigate the polymorphism of KIR genes in systemic lupus erythematosus（SLE） patients,and to study the correlation between KIR genes and susceptibility of SLE.METHODS： The polymorphism of KIR genes were detected by PCR-SSP technique in 62 patients with SLE and 61 healthy persons as controls from North of China.RESULTS： The differences of KIR frequency between the SLE group and the control were tested by statistical analysis.The most frequent genotype was KIR 3DP1,2DL1,2DP1,3DL1,2DL3,1D,followed by 2DS4,2DL5,3DS1,2DS2,2DS5 and 2DL2.KIR 2DS1,2DS3 and 3DP1v were lower in frequency compared with others.The frequency of KIR 3DS1,2DL2,2DL5 and 2DL3 were significantly lower in SLE group than that in the control（P〈0.01）.CONCLUSION： There may be a association between the polymorphism of KIR genes with SLE in North of China should be investigated further.

关 键 词：系统性红斑狼疮 KIR基因 多态性 

分 类 号：R733.17[医药卫生—肿瘤] R593.24[医药卫生—临床医学]