由蛋白质分子构筑的织构复合水凝胶体系  

Textural composite hydrogel system constructed with protein molecules

作　　者：朴东旭[1] 毛立江[1] 胡元洁[1] 陈晓东[1] 朴春花[1] 

机构地区：[1]中国康复研究中心高分子材料研究室,北京市100068

出　　处：《中国组织工程研究与临床康复》2008年第23期4519-4521,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：初步查明骨骼肌组织中的蛋白质水凝胶复合元件及其织构复合水凝胶体系的存在性和行为特性。以有关肌组织的生物学及水凝胶材料的化学方面的既往研究结果为求证依据,对于织构复合水凝胶体系假说的合理性进行论证。可以推断:①在肌组织中,某些蛋白质分子(如G-肌动蛋白、肌球蛋白、原肌球蛋白、肌钙蛋白等)分别与水分子结合构成相应的水凝胶复合元件。这些水凝胶复合元件通过特定的组合、排列逐级地构筑一系列多层次的织构复合水凝胶体系:肌丝、肌原纤维、肌细胞、肌束、肌肉。②取自动物肌组织的某些蛋白质水凝胶复合元件具有独立性和可控性。在体外可以由这些蛋白质水凝胶复合元件构筑某种驱动型水凝胶纳米机器。The aim of the present research is to primarily find out the existence and behavior of the hydrogel composite elements （HCEs） and their textural composite hydrogel system （TCHS） in the skeletal muscle tissues. Rationality of the TCHS hypothesis would be proven by using previous research results concerning muscle tissue-biology and hydrogel chemistry as evidences. It was deduced thai： There must be some HCEs which could be formed respectively from some protein molecules （such as G-actin, myosin, tropomyosin and troponin） and water molecules in the skeletal muscle tissues. Such HCEs can gradually construct a series of hierarchical TCHS （myofilament, myofibril, muscle fiber, muscle bundle, muscle） through specified ways of combination and permutation. Some protein HCEs obtained from animal muscle tissues show independent character and controllability, and the driving hydrogel nano-machine can be constructed from these protein HCEs.

关 键 词：蛋白质分子 水凝胶元件 织构复合水凝胶体系 骨骼肌 生物材料 

分 类 号：R318[医药卫生—生物医学工程]