癌基因STAT3与结直肠癌恶性程度关系的研究  

The research on the relationship of oncogene STAT3 and malignancy degree in colorectal carcinoma

作　　者：石仁芳[1] 唐国都[2] 李运千[3] 

机构地区：[1]桂林医学院附属医院消化内科,广西桂林541001 [2]广西医科大学第一附属医院消化内科,广西南宁530021 [3]桂林医学院附属医院病理科,广西桂林541001

出　　处：《华夏医学》2008年第3期419-420,共2页Acta Medicinae Sinica

摘　　要：目的:通过研究癌基因STAT3在结直肠癌及癌旁组织中的表达,探讨其在结直肠癌发病机制中的作用。方法:采用免疫组化MaxVisionTM法检测40例结直肠癌组织、37例癌旁组织和30例正常肠粘膜组织中STAT3蛋白的表达,并对结直肠癌组织中STAT3蛋白的表达情况与不同临床病理特征进行统计学分析。结果:在结直肠癌和癌旁组织中,STAT3蛋白的表达差异无显著性(P>0.05)。相对于正常肠粘膜组织,结直肠癌和癌旁组织的STAT3蛋白表达有显著差异(P<0.05)。STAT3蛋白的表达水平与结直肠癌的分化程度、临床分期及淋巴结转移有关(P<0.05).结论:STAT3高表达可能是结直肠癌发病机制中的早期事件。在癌旁组织中,那些STAT3蛋白阳性的组织细胞可能是潜在的癌前细胞。检测结直肠癌中STAT3蛋白的表达可以反映肿瘤的恶性程度。Objective：By researching the expression oncogene STAT3 in colorectal carcinoma（CRC）tissues and para- carcinoma tissues,to explore its role mechanism in tumorigenesis of CRC.Methods：The protein expressions of STAT3 were detected in 40 CRC tissues,37 para-carcinoma tissues and 30 normal colorectal mucosa tissues by Max VisionTM immunohistochemistry,and the relationship of the expression of STAT3 in CRC with various clinicopatholoical characteristics was analyzed statistically.Results：There was no significant difference between the expression of STAT3 protein in CRC tissues and para-carcinoma tissues（P〉0.05）.Compared with normal colorectal mu- cosa tissues,the expression of STAT3 protein in CRC tissues and para-carcinoma were significantly higher（P〈0.05）.Overexpression of STAT3 protein was correlated with differentiation,clinical stage and lymph node metastasis in CRC（P〈0.05）.Conclusions：Overexpression of STAT3 may be an early accidence in the pathogenesis of CRC.In para-carcinoma tissues,those STAT3-positive may be potential pre-cancerous cells.Determination of STAT3 protein can be used to indicate the malignancy degree of CRC.

关 键 词：癌基因 STAT3 结肠直肠肿瘤 免疫组织化学 

分 类 号：R735.37[医药卫生—肿瘤] R446.8[医药卫生—临床医学]