c-FLIP/Ki-67在膀胱癌中的表达对预后影响的研究  

Research of c-FLIP and Ki-67 Expression in Bladder Urothelial Carcinomas and Their Relation to Clinical Pathology and Prognosis

作　　者：渠武帅[1] 马金生[1] 李大伟[1] 杨树立[1] 白淑贞[1] 

机构地区：[1]河南省平顶山市第一人民医院,河南平顶山467000

出　　处：《中国现代医生》2008年第18期52-53,共2页China Modern Doctor

摘　　要：目的研究膀胱癌中c-FLIP和Ki-67的表达与肿瘤分期、分级和生长方式以及患者预后的关系,从而为膀胱移行细胞癌侵袭性和预后的判断提供科学理论依据。方法收集56例临床资料完整石蜡包埋的肿瘤标本,用免疫组化SABC法测定c-FLIP、Ki-67的表达,采用SPSS12.0软件包分析其表达与肿瘤组织学性状的关系以及对患者预后的影响。结果c-FLIP、Ki-67的阳性表达在56个病例中分别为:64%(36/56)、59%(33/56);多因素生存分析发现c-FLIP、生长方式和分期对生存影响具有显著性意义。结论c-FLIP对评价膀胱癌的侵袭性和对预后的影响是一个重要的独立因素,Ki-67对评价膀胱癌的侵袭性和预后也有一定的意义。Objective To investigate the expression of c-FLIP and Ki-67 in bladder urothelial carcinomas in relation to tumor grade, stage and growth type. To investigate these factors in relation to patient outcome in bladder urothelial carcinomas. And then to provide scientific theory evidence for judgment on severity of the tumor and prognosis of patient with bladder urothelial carcinomas. Methods The expression of c-FLIP and Ki-67 was quantified immunohistochemiclly in paraffin-embedded tumor tissues from 56 patients for whom clinical information was available. The relationship between their expression and histologic findings and the effect of these factors on clinical outcome was assessed by SPSS12.0 software. Results Positive incidence of expression in bladder urothelial carcinomas was detected for c-FLIP and Ki-67 was in 64%（36/56） and 59%（33/56） of cases, respectively. We found tumor growth type, stage, c-FLIP affected patient outcome significantly in multivariate survival analysis. Conclusion c-FLIP is an important independent factor for its value of assessing the severity of tumor and prognosis. Ki-67 is also significant for assessing the severity of tumor and prognosis to some extent.

关 键 词：膀胱移行细胞癌 c—FLIP KI-67 表达 预后 

分 类 号：R737.14[医药卫生—肿瘤]