BVT．2733对肥胖小鼠胰岛素抵抗及炎症指标的影响  

The effect of BVT.2733 on insulin resistance and inflammation in obesity mice

作　　者：朱亭[1] 谢宇[1] 刘娟[1] 钟毅[2] 丁国宪[1] 

机构地区：[1]南京医科大学第一附属医院老年医学科,江苏南京210029 [2]中国药科大学药化教研室,江苏南京210009

出　　处：《南京医科大学学报（自然科学版）》2008年第8期968-972,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助(30570878)

摘　　要：目的:观察BVT.2733对饮食诱导的肥胖小鼠胰岛素抵抗及炎症指标的影响。方法:建立饮食诱导的肥胖模型小鼠,并将其分为肥胖组和BVT.2733治疗组。肥胖组给予安慰剂;治疗组给予BVT.2733灌胃两周,另设正常饲养的小鼠为正常组,检测小鼠体内代谢及炎症相关指标,观察三组小鼠在胰岛素抵抗以及炎症方面的差异。结果:与正常组相比,肥胖组小鼠脂肪细胞明显增大,体重增加,空腹血糖、血清胰岛素及TNF-α升高,脂肪组织TLR4 mRNA表达增高,经BVT.2733治疗后,肥胖鼠脂肪细胞体积减小,体重减轻,空腹血糖、血清胰岛素明显下降,脂肪组织TLR4 mRNA表达减少,而血TNF-α没有显著变化。结论:BVT.2733能改善肥胖小鼠的胰岛素抵抗并且降低脂肪组织TLR4 mRNA的表达,而对于血清TNF-α水平没有明显的影响。Objective：To investigate the effect of BVT.2733 on insulin resistance （IR） and inflammation in diet-induced obesity （DIO）mice. Methods：Male mice were divided into normal mice and model mice after fed with normal diet and high-fat diet for 20 weeks,respectively. The model mice were subdivided into BVT.2733 mice administrated with BVT.2733 and obesity mice with placebo for 2 weeks. Indexes related with metabolism and inflammation were measured. Results：Compared with normal mice, adipocytes were significantly enlarged in obesity mice, and body weight also increased. Similarly, blood glucose, serum insulin and TNF-α, the expression of TLR4 mRNA in adipose tissue were all increased. After administration of BVT.2733,adipocytes were diminished; body weight, blood glucose,serum insulin,and the expression of TLR4 mRNA in adipose tissue were all decreased. But there was no significant change in serum TNF-α. Conclusion：BVT.2733 can improve IR and decrease the expression of TLR4 mRNA in adipose tissue,but have little effect on serum TNF-α in DIO mice.

关 键 词：肥胖 胰岛素抵抗 炎症 11β-HSD1抑制剂 

分 类 号：R589.2[医药卫生—内分泌]