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机构地区:[1]南方医科大学南方医院血液科,广州市510515
出 处:《实用医学杂志》2008年第12期2028-2030,共3页The Journal of Practical Medicine
基 金:广东省社会发展攻关项目(编号:B30202)
摘 要:目的:观察重组人白细胞介素11(rhIL-11)联合重组人粒细胞集落刺激因子(rhG-CSF)动员自体外周血干细胞治疗急性白血病的效果及不良反应。方法:急性白血病患者14例,其中治疗组6例(实验组)在化疗后外周血白细胞计数降至最低时,皮下注射rhIL-113μg/d及rhG-CSF250μg/d,连用至外周血白细胞升高至10×109/L左右时(采集干细胞时)停药。单用rhG-CSF组为对照组。结果:采集前外周血血小板、CD34+细胞数实验组高于对照组(P<0.05),采集产品的CD34+、CD34+/CD38-、CD34+/CD41a+、CD34+/CD42b+细胞数实验组均高于对照组(P<0.05);移植后实验组血小板>20×109/L平均时间为14.5d,对照组为20.2d(P=0.06)。不良反应主要是肌肉关节疼痛及水肿,均为Ⅰ~Ⅱ级。结论:rhIL-11与rhG-CSF动员外周血干细胞治疗急性白血病安全有效。Objective To observe the efficacy and toxicity of recombinant human interleukin 11 (rhIL-11)in combination with granulocyte-colony stimulating factor (rhG-CSF) on mobilization of autologous peripheral blood stem cells (APBSC) in acute leukemia patients. Methods Six acute leukemia patients were enrolled in the test group, rh IL-11 3 μg/d and rh G-CSF 250μg/d were subcutaneously injected from the day of the nadir of white blood cell(WBC) to the day before the end of APBCS harvest, APBSC harvest started when WBC ≥ 10r10^9/L. The other 8 patients without treatment of rhIL-11 were the control group, Results rhIL-11 in combination with rh G-CSF resulted in increase in the number of platelet, CD34^+ cells in peripheral blood,which were more than those of the control group (P 〈 0,05), The yields of CD34^+, CD34^+/CD38^-, CD34^+/CD41a^+ and CD34^+/CD42b^+ were significantly more than that of rhG-CSF group (P 〈 0.05). After APBSC, the time average for platelet to recover up the level of 20 × 10^9/L was + 14.5 days in test group and + 20.2 days in control group respectively, and there was no significant difference (P = 0.06). The major adverse event associated with rhIL-11 were myalgia/arthralgia, edema and the degree of these were all Ⅰ- Ⅱ grade. Conclusion rhIL- 11 in combination with rhG-CSF could significantly mobilize hematopoietic stem/progenitor cells from bone marrow into peripheral blood, which is a safe and highly effective method for APBSC mobilization.
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