重组人白细胞介素11联合重组人粒细胞集落刺激因子动员自体外周血干细胞移植治疗急性白血病  被引量:3

Mobilization of autologous peripheral blood stem cells with recombinant human interleukin11 in combination with recombinant human granulocyte colony stimulating factor in acute leukemia

在线阅读下载全文

作  者:徐丹[1] 孟凡义[1] 易正山[1] 孙竞[1] 

机构地区:[1]南方医科大学南方医院血液科,广州市510515

出  处:《实用医学杂志》2008年第12期2028-2030,共3页The Journal of Practical Medicine

基  金:广东省社会发展攻关项目(编号:B30202)

摘  要:目的:观察重组人白细胞介素11(rhIL-11)联合重组人粒细胞集落刺激因子(rhG-CSF)动员自体外周血干细胞治疗急性白血病的效果及不良反应。方法:急性白血病患者14例,其中治疗组6例(实验组)在化疗后外周血白细胞计数降至最低时,皮下注射rhIL-113μg/d及rhG-CSF250μg/d,连用至外周血白细胞升高至10×109/L左右时(采集干细胞时)停药。单用rhG-CSF组为对照组。结果:采集前外周血血小板、CD34+细胞数实验组高于对照组(P<0.05),采集产品的CD34+、CD34+/CD38-、CD34+/CD41a+、CD34+/CD42b+细胞数实验组均高于对照组(P<0.05);移植后实验组血小板>20×109/L平均时间为14.5d,对照组为20.2d(P=0.06)。不良反应主要是肌肉关节疼痛及水肿,均为Ⅰ~Ⅱ级。结论:rhIL-11与rhG-CSF动员外周血干细胞治疗急性白血病安全有效。Objective To observe the efficacy and toxicity of recombinant human interleukin 11 (rhIL-11)in combination with granulocyte-colony stimulating factor (rhG-CSF) on mobilization of autologous peripheral blood stem cells (APBSC) in acute leukemia patients. Methods Six acute leukemia patients were enrolled in the test group, rh IL-11 3 μg/d and rh G-CSF 250μg/d were subcutaneously injected from the day of the nadir of white blood cell(WBC) to the day before the end of APBCS harvest, APBSC harvest started when WBC ≥ 10r10^9/L. The other 8 patients without treatment of rhIL-11 were the control group, Results rhIL-11 in combination with rh G-CSF resulted in increase in the number of platelet, CD34^+ cells in peripheral blood,which were more than those of the control group (P 〈 0,05), The yields of CD34^+, CD34^+/CD38^-, CD34^+/CD41a^+ and CD34^+/CD42b^+ were significantly more than that of rhG-CSF group (P 〈 0.05). After APBSC, the time average for platelet to recover up the level of 20 × 10^9/L was + 14.5 days in test group and + 20.2 days in control group respectively, and there was no significant difference (P = 0.06). The major adverse event associated with rhIL-11 were myalgia/arthralgia, edema and the degree of these were all Ⅰ- Ⅱ grade. Conclusion rhIL- 11 in combination with rhG-CSF could significantly mobilize hematopoietic stem/progenitor cells from bone marrow into peripheral blood, which is a safe and highly effective method for APBSC mobilization.

关 键 词:白血病 白细胞介素11 粒细胞集落刺激因子 造血干细胞动员 

分 类 号:R733.71[医药卫生—肿瘤]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象