肝细胞生长因子拮抗剂NK4对人舌鳞癌细胞株Tca-8113侵袭能力的影响  

Effect of NK4,an Antagonist of Hepatocyte Growth Factor on Migration of Human Tongue Squamous Carcinoma Cell Line Tca8113

作　　者：常红梅[1] 李美宁[2] 张悦红[2] 刘志贞[2] 张栋[2] 

机构地区：[1]太原市人民医院,山西太原030001 [2]山西医科大学生物化学与分子生物学教研室,山西太原030001

出　　处：《实用医技杂志》2008年第22期2890-2892,共3页Journal of Practical Medical Techniques

摘　　要：目的:研究不同浓度NK4因子对人舌鳞癌细胞株Tca-8113侵袭能力的影响。方法:采用基底膜侵袭实验观察不同浓度NK4因子对人舌鳞癌细胞株Tca-8113侵袭能力的影响。结果:在浓度为10μg/ml时,NK4因子对人舌鳞癌细胞株Tca-8113侵袭重组基底膜的抑制率为56.4%。结论:NK4因子具有抑制肿瘤细胞人舌鳞癌细胞株Tca-8113侵袭的能力。Objective To detect the activity that NK4 effect migration of human tongue squamous carcinoma.Methods We have preparated a novel kind of protein factor-NK4 which can antagonize tumor. Then the activity that NK4 antagonize tumor were detected by the Transwell Migration Assay. Results NK4 could suppress the migration of human tongue squamous carcinoma cells dose-dependently. The suppression rate of NK4 groups were significantly greater than that of control group. Conclusion NK4 is an angiogenesis inhibitor that suppresses tumor metastasis.

关 键 词：NK4 人舌鳞癌细胞 侵袭 

分 类 号：R739.8[医药卫生—肿瘤]